TY - JOUR
T1 - Dimethyl sulphoxide reduces anti-receptor antibody titres in experimental myasthenia gravis
AU - Pestronk, Alan
AU - Drachman, Daniel B.
PY - 1980/12/1
Y1 - 1980/12/1
N2 - The basic abnormality in myasthenia gravis (MG) is a reduction of acetylcholine receptors (AChRs) at neuromuscular junctions, due to an autoimmune attack directed against the receptors1. Several lines of evidence support the idea that humoral immune mechanisms play an important part in this process: anti-AChR antibodies are present in the sera of more than 80% of myasthenic patients2-4; the pathogenicity of the antibodies has been demonstrated by passive transfer of IgG from myasthenic patients to mice which reproduces the typical features of MG in the recipient animals5,6; finally, procedures that reduce levels of anti-AChR antibody, such as plasmapheresis, produce improvement in the clinical symptoms of MG7. Present treatments of MG depend largely on the prolonged use of immunosuppressive drugs, which have significant drawbacks1,8-10, for they usually produce only a slow fall in antibody titres, and have toxic side effects. An agent that could produce a rapid and sustained fall of autoantibody titre might have wide application in the treatment of MG and other autoimmune diseases. In the course of testing immunosuppressive drugs for their effect in treating experimental autoimmune MG (EAMG), we discovered that the vehicle used to dissolve some of these agents, dimethyl sulphoxide (DMSO), itself produced a rapid and sustained fall of anti-AChR antibody titre. We now report similar results for a controlled trial of DMSO treatment in rats with EAMG.
AB - The basic abnormality in myasthenia gravis (MG) is a reduction of acetylcholine receptors (AChRs) at neuromuscular junctions, due to an autoimmune attack directed against the receptors1. Several lines of evidence support the idea that humoral immune mechanisms play an important part in this process: anti-AChR antibodies are present in the sera of more than 80% of myasthenic patients2-4; the pathogenicity of the antibodies has been demonstrated by passive transfer of IgG from myasthenic patients to mice which reproduces the typical features of MG in the recipient animals5,6; finally, procedures that reduce levels of anti-AChR antibody, such as plasmapheresis, produce improvement in the clinical symptoms of MG7. Present treatments of MG depend largely on the prolonged use of immunosuppressive drugs, which have significant drawbacks1,8-10, for they usually produce only a slow fall in antibody titres, and have toxic side effects. An agent that could produce a rapid and sustained fall of autoantibody titre might have wide application in the treatment of MG and other autoimmune diseases. In the course of testing immunosuppressive drugs for their effect in treating experimental autoimmune MG (EAMG), we discovered that the vehicle used to dissolve some of these agents, dimethyl sulphoxide (DMSO), itself produced a rapid and sustained fall of anti-AChR antibody titre. We now report similar results for a controlled trial of DMSO treatment in rats with EAMG.
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U2 - 10.1038/288733a0
DO - 10.1038/288733a0
M3 - Article
C2 - 7453805
AN - SCOPUS:0019194270
SN - 0028-0836
VL - 288
SP - 733
EP - 734
JO - Nature
JF - Nature
IS - 5792
ER -