Diffusion Tensor Imaging of the Optic Tracts in Multiple Sclerosis: Association with Retinal Thinning and Visual Disability

Hormuzdiyar H. Dasenbrock, Seth A. Smith, Arzu Ozturk, Sheena K. Farrell, Peter A. Calabresi, Daniel Salo Reich

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


BACKGROUND AND PURPOSE: Visual disability is common in multiple sclerosis, but its relationship to abnormalities of the optic tracts remains unknown. Because they are only rarely affected by lesions, the optic tracts may represent a good model for assessing the imaging properties of normal-appearing white matter in multiple sclerosis. METHODS: Whole-brain diffusion tensor imaging was performed on 34 individuals with multiple sclerosis and 26 healthy volunteers. The optic tracts were reconstructed by tractography, and tract-specific diffusion indices were quantified. In the multiple-sclerosis group, peripapillary retinal nerve-fiber-layer thickness and total macular volume were measured by optical coherence tomography, and visual acuity at 100%, 2.5%, and 1.25% contrast was examined. RESULTS: After adjusting for age and sex, optic-tract mean and perpendicular diffusivity were higher (P=.002) in multiple sclerosis. Lower optic-tract fractional anisotropy was correlated with retinal nerve-fiber-layer thinning (r=.51, P=.003) and total-macular-volume reduction (r=.59, P=.002). However, optic-tract diffusion indices were not specifically correlated with visual acuity or with their counterparts in the optic radiation. CONCLUSIONS: Optic-tract diffusion abnormalities are associated with retinal damage, suggesting that both may be related to optic-nerve injury, but do not appear to contribute strongly to visual disability in multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)e41-e49
JournalJournal of Neuroimaging
Issue number2
StatePublished - Apr 2011


  • Diffusion tensor imaging
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Optic neuritis
  • Optic tract
  • Optical coherence tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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