Abstract
Marchiafava-Bignami disease, a rare disorder most commonly seen in patients with a history of alcohol consumption, involves demyelination and subsequent necrosis of the corpus callosum. Diffusion tensor imaging demonstrates regional abnormalities in the corpus callosum that are not evident by conventional magnetic resonance imaging (MRI). Furthermore, fiber-tracking demonstrates significant disruption of axonal fiber bundles within the corpus callosum, most marked within the body, corresponding to the clinical finding of interhemispheric disconnection, which is characteristic of the disease.
Original language | English (US) |
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Pages (from-to) | 281-285 |
Number of pages | 5 |
Journal | Journal of Neuroimaging |
Volume | 16 |
Issue number | 3 |
DOIs | |
State | Published - Jul 2006 |
Externally published | Yes |
Keywords
- Diffusion tensor imaging
- MR tractography
- Marchiafava-Bignami disease
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology