Diffusion tensor imaging and fiber-tracking in marchiafava-bignami disease

Haris I. Sair, Feroze B. Mohamed, Sunil Patel, Uday S. Kanamalla, Beverly Hershey, Zakaria Hakma, Scott H. Faro

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Marchiafava-Bignami disease, a rare disorder most commonly seen in patients with a history of alcohol consumption, involves demyelination and subsequent necrosis of the corpus callosum. Diffusion tensor imaging demonstrates regional abnormalities in the corpus callosum that are not evident by conventional magnetic resonance imaging (MRI). Furthermore, fiber-tracking demonstrates significant disruption of axonal fiber bundles within the corpus callosum, most marked within the body, corresponding to the clinical finding of interhemispheric disconnection, which is characteristic of the disease.

Original languageEnglish (US)
Pages (from-to)281-285
Number of pages5
JournalJournal of Neuroimaging
Issue number3
StatePublished - Jul 2006
Externally publishedYes


  • Diffusion tensor imaging
  • MR tractography
  • Marchiafava-Bignami disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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