Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome

Florian S. Eichler, Paul Wang, Robert J. Wityk, Norman J. Beauchamp, Peter B. Barker

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Two cases of reversible posterior leukoencephalopathy syndrome were examined with proton MR spectroscopic imaging. Widespread metabolic abnormalities, consisting of increased choline and creatine levels and mildly decreased N-acetylaspartate, occurred in regions with both normal and abnormal MR imaging appearances. In one case for which proton MR spectroscopic imaging follow-up was available, all metabolite levels had returned to normal by 2 months. Proton MR spectroscopic imaging may be helpful for the diagnosis and investigation of the underlying pathophysiology of reversible posterior leukoencephalopathy syndrome.

Original languageEnglish (US)
Pages (from-to)833-837
Number of pages5
JournalAmerican Journal of Neuroradiology
Issue number5
StatePublished - May 28 2002

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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