Differentiation of Blast Cells in Acute Nonlymphocytic Leukemia

M. M. Reid, Eric R. Fearon, Philip J. Burke, Barbara A. Zehnbauer, Bert Vogelstein, Charles A. Schiffer

Research output: Contribution to journalLetterpeer-review

14 Scopus citations


To the Editor: Fearon et al. (July 3 issue)1 overinterpret their data. Their elegant work on clonal abnormalities in acute nonlymphocytic leukemia provides evidence that in some patients both blast forms and mature granulocytes are clonally related. The “preleukemic hypothesis” to which they redirect our attention is attractive and supported by their data. However, the authors do not demonstrate that leukemic blast cells can differentiate in vivo to mature peripheral-blood polymorphonuclear leukocytes. That is but one interpretation of their data, and it remains as untested as it was when a similar discussion appeared in the Journal in 1983.2 If one.

Original languageEnglish (US)
Pages (from-to)1488
Number of pages1
JournalNew England Journal of Medicine
Issue number23
StatePublished - Dec 4 1986

ASJC Scopus subject areas

  • General Medicine


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