Differential Vascularity in Genetic and Nonhereditary Heterotopic Ossification

Alisha D. Ware, Niambi Brewer, Carolyn Meyers, Carol Morris, Edward McCarthy, Eileen M. Shore, Aaron W. James

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Introduction. Nonhereditary heterotopic ossification (NHO) is a common complication of trauma. Progressive osseous heteroplasia (POH) and fibrodysplasia ossificans progressiva (FOP) are rare genetic causes of heterotopic bone. In this article, we detail the vascular patterning associated with genetic versus NHO. Methods. Vascular histomorphometric analysis was performed on patient samples from POH, FOP, and NHO. Endpoints for analysis included blood vessel (BV) number, area, density, size, and wall thickness. Results. Results demonstrated conserved temporal dynamic changes in vascularity across all heterotopic ossification lesions. Immature areas had the highest BV number, while the more mature foci had the highest BV area. Most vascular parameters were significantly increased in genetic as compared with NHO. Discussion. In sum, both genetic and NHO show temporospatial variation in vascularity. These findings suggest that angiogenic pathways are potential therapeutic targets in both genetic and nonhereditary forms of heterotopic ossification.

Original languageEnglish (US)
Pages (from-to)859-867
Number of pages9
JournalInternational journal of surgical pathology
Issue number8
StatePublished - Dec 1 2019


  • angiogenesis
  • fibrodysplasia ossificans progressive
  • heterotopic bone
  • heterotopic ossification
  • progressive heterotopic ossification

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine


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