Differential utilization of calcitonin gene regulatory DNA sequences in cultured lines of medullary thyroid carcinoma and small-cell lung carcinoma

Andrée De Bustros; Ree Y. Lee; Debra Compton; Tian Y. Tsong; Stephen B. Baylin; Barry D. Nelkin

doi:10.1128/MCB.10.4.1773

Differential utilization of calcitonin gene regulatory DNA sequences in cultured lines of medullary thyroid carcinoma and small-cell lung carcinoma

Andrée De Bustros, Ree Y. Lee, Debra Compton, Tian Y. Tsong, Stephen B. Baylin, Barry D. Nelkin

School of Medicine

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Regulation of expression of the human calcitonin gene was found to differ between two tumor lines of different tissue origin, medullary thyroid carcinoma (TT line) and small-cell lung carcinoma (DMS53 line). Distal 5′ DNA elements between -750 and -2000 exhibited a stronger basal activity in DMS53 than in TT cells, whereas proximal DNA sequences between -132 and -252 mediated a dramatic cyclic AMP response in TT but not DMS53 cells.

Original language	English (US)
Pages (from-to)	1773-1778
Number of pages	6
Journal	Molecular and cellular biology
Volume	10
Issue number	4
DOIs	https://doi.org/10.1128/MCB.10.4.1773
State	Published - 1990

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Access to Document

10.1128/MCB.10.4.1773

Cite this

@article{557df286347e43c384278d98250399f2,

title = "Differential utilization of calcitonin gene regulatory DNA sequences in cultured lines of medullary thyroid carcinoma and small-cell lung carcinoma",

abstract = "Regulation of expression of the human calcitonin gene was found to differ between two tumor lines of different tissue origin, medullary thyroid carcinoma (TT line) and small-cell lung carcinoma (DMS53 line). Distal 5′ DNA elements between -750 and -2000 exhibited a stronger basal activity in DMS53 than in TT cells, whereas proximal DNA sequences between -132 and -252 mediated a dramatic cyclic AMP response in TT but not DMS53 cells.",

author = "{De Bustros}, Andr{\'e}e and Lee, {Ree Y.} and Debra Compton and Tsong, {Tian Y.} and Baylin, {Stephen B.} and Nelkin, {Barry D.}",

year = "1990",

doi = "10.1128/MCB.10.4.1773",

language = "English (US)",

volume = "10",

pages = "1773--1778",

journal = "Molecular and cellular biology",

issn = "0270-7306",

publisher = "Taylor and Francis Ltd.",

number = "4",

}

TY - JOUR

T1 - Differential utilization of calcitonin gene regulatory DNA sequences in cultured lines of medullary thyroid carcinoma and small-cell lung carcinoma

AU - De Bustros, Andrée

AU - Lee, Ree Y.

AU - Compton, Debra

AU - Tsong, Tian Y.

AU - Baylin, Stephen B.

AU - Nelkin, Barry D.

PY - 1990

Y1 - 1990

N2 - Regulation of expression of the human calcitonin gene was found to differ between two tumor lines of different tissue origin, medullary thyroid carcinoma (TT line) and small-cell lung carcinoma (DMS53 line). Distal 5′ DNA elements between -750 and -2000 exhibited a stronger basal activity in DMS53 than in TT cells, whereas proximal DNA sequences between -132 and -252 mediated a dramatic cyclic AMP response in TT but not DMS53 cells.

AB - Regulation of expression of the human calcitonin gene was found to differ between two tumor lines of different tissue origin, medullary thyroid carcinoma (TT line) and small-cell lung carcinoma (DMS53 line). Distal 5′ DNA elements between -750 and -2000 exhibited a stronger basal activity in DMS53 than in TT cells, whereas proximal DNA sequences between -132 and -252 mediated a dramatic cyclic AMP response in TT but not DMS53 cells.

UR - http://www.scopus.com/inward/record.url?scp=0025216171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025216171&partnerID=8YFLogxK

U2 - 10.1128/MCB.10.4.1773

DO - 10.1128/MCB.10.4.1773

M3 - Article

C2 - 2157143

AN - SCOPUS:0025216171

SN - 0270-7306

VL - 10

SP - 1773

EP - 1778

JO - Molecular and cellular biology

JF - Molecular and cellular biology

IS - 4

ER -

Differential utilization of calcitonin gene regulatory DNA sequences in cultured lines of medullary thyroid carcinoma and small-cell lung carcinoma

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this