TY - JOUR
T1 - Differential sulphation of chondroitins in murine T and B lymphocytes and lymphoma cells
AU - Rider, Christopher C.
AU - Hart, Gerald Warren
PY - 1987
Y1 - 1987
N2 - Splenic B and T lymphocytes metabolically labelled in vitro with [35S]-H2SO4 show differential sulphation of chondroitin sulphate, the major sulphated glycosaminoglycan in both cell-retained and secreted fractions. In B cells, 6-O-sulphation is more abundant than 4-O-sulphation, whereas in T cells sulphation occurs predominantly in the 4-O-position. The murine lymphoma lines AKTB-1b and EL-4, of B and T origin respectively, show even more marked differences. AKTB-1b follows the pattern of normal B cells, whilst in EL-4 only chondroitin 4-sulphate is synthesized.
AB - Splenic B and T lymphocytes metabolically labelled in vitro with [35S]-H2SO4 show differential sulphation of chondroitin sulphate, the major sulphated glycosaminoglycan in both cell-retained and secreted fractions. In B cells, 6-O-sulphation is more abundant than 4-O-sulphation, whereas in T cells sulphation occurs predominantly in the 4-O-position. The murine lymphoma lines AKTB-1b and EL-4, of B and T origin respectively, show even more marked differences. AKTB-1b follows the pattern of normal B cells, whilst in EL-4 only chondroitin 4-sulphate is synthesized.
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U2 - 10.1016/0161-5890(87)90007-1
DO - 10.1016/0161-5890(87)90007-1
M3 - Article
C2 - 3116414
AN - SCOPUS:0023229477
SN - 0161-5890
VL - 24
SP - 963
EP - 967
JO - Molecular Immunology
JF - Molecular Immunology
IS - 9
ER -