@article{1529c8e249b34def8d7b960f18c19c0c,
title = "Differential encoding in prefrontal cortex projection neuron classes across cognitive tasks",
abstract = "Bridging molecular and systems neuroscience perspectives, Lui et al.",
keywords = "cell type atlas, cognitive behavior task, mini-endoscopic Ca imaging, molecular neuroscience, prefrontal cortex, projection mapping, systems neuroscience, transcriptomic neuron type, two-alternative forced choice",
author = "Lui, {Jan H.} and Nguyen, {Nghia D.} and Grutzner, {Sophie M.} and Spyros Darmanis and Diogo Peixoto and Wagner, {Mark J.} and Allen, {William E.} and Kebschull, {Justus M.} and Richman, {Ethan B.} and Jing Ren and Newsome, {William T.} and Quake, {Stephen R.} and Liqun Luo",
note = "Funding Information: We thank E. Kremer for CAV-Cre virus; A. Mizrahi, D. Pederick, and L. DeNardo for critical comments on the manuscript; L. Driscoll and Luo Lab members for helpful discussion and reagents; L. Schwarz for pilot in situ hybridization experiments; L. Murrow for scRNAseq analysis advice; R. Jones and S. Kolluru for technical help with scRNAseq and data management; C. Tsang, L. Cardy, and A. Thomas for Inscopix technical help; and M. Andermann for supporting N.D.N. to work on this project after leaving Stanford. J.H.L. is supported by an NIMH K01-MH114022 grant. S.R.Q. is a Biohub investigator. L.L. is an HHMI investigator. This work was supported by an NIH grant ( R01-NS050835 ) and an NSF NeuroNex grant. Funding Information: We thank E. Kremer for CAV-Cre virus; A. Mizrahi, D. Pederick, and L. DeNardo for critical comments on the manuscript; L. Driscoll and Luo Lab members for helpful discussion and reagents; L. Schwarz for pilot in situ hybridization experiments; L. Murrow for scRNAseq analysis advice; R. Jones and S. Kolluru for technical help with scRNAseq and data management; C. Tsang, L. Cardy, and A. Thomas for Inscopix technical help; and M. Andermann for supporting N.D.N. to work on this project after leaving Stanford. J.H.L. is supported by an NIMH K01-MH114022 grant. S.R.Q. is a Biohub investigator. L.L. is an HHMI investigator. This work was supported by an NIH grant (R01-NS050835) and an NSF NeuroNex grant. J.H.L. and L.L. conceived the project. J.H.L. performed and analyzed the scRNAseq experiments, did all surgeries, trained mice, supervised the behavioral experiments, and analyzed data. N.D.N. designed and wrote all the code for the behavioral systems, trained and imaged mice, and analyzed imaging data. S.M.G. performed optogenetics, HCR-FISH, and analyzed data. S.D. trained J.H.L. in scRNAseq and data analysis. M.J.W. helped in imaging data analysis. W.E.A. designed an original version of the behavioral system and helped in data analysis. J.M.K. helped with scRNAseq data management and analysis. E.B.R. aided in image segmentation. J.R. performed the amygdala injections. D.P. and W.T.N. offered critical guidance in behavioral task design and imaging data analysis. S.R.Q. supported the scRNAseq, and guided data analysis. L.L. supervised the entire project. J.H.L. N.D.N. and L.L. wrote the manuscript. All authors edited the manuscript. The authors have no competing interests. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = jan,
day = "21",
doi = "10.1016/j.cell.2020.11.046",
language = "English (US)",
volume = "184",
pages = "489--506.e26",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",
}