Differential effects of estrogen treatment of canine seminal plasma components

J. T. Isaacs, W. B. Isaacs, L. G. Wheaton, D. S. Coffey

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


In castrate dogs, complete androgen-dependent restoration of seminal plasma content of fluid, electrolytes, and protein was induced by testosterone treatment alone. In contrast, a combination of androgen and estrogen treatment selectively reduced only the androgen induced stimulation of the electrolyte and fluid components without altering the total amount of protein secreted. Spontaneous cystic prostatic hyperplasia was found to be characterized by a similar decrease in total fluid and electrolyte content without a concomitant decrease in the total amount of protein in the seminal plasma. These results suggest that prostatic protein secretion may be a process distinct from electrolyte-fluid transport because either estradiol treatment or the development of spontaneous cystic prostatic hyperplasia dissociates these two processes.

Original languageEnglish (US)
Pages (from-to)495-498
Number of pages4
JournalInvestigative Urology
Issue number6
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Medicine(all)


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