TY - JOUR
T1 - Differential detection of metastatic and inflammatory lymph nodes using inflow-based vascular-space-occupancy (iVASO) MR imaging
AU - Guo, Liuji
AU - Liu, Xiaomin
AU - Hua, Jun
AU - Dai, Lin
AU - Tao, Ying
AU - Cao, Haimei
AU - Qin, Jie
AU - Li, Xiaodan
AU - Wu, Yuankui
N1 - Funding Information:
The authors thank X.S. Li for the help of histopathological evaluation. This work was supported in part by the Natural Science Foundation of Guangdong Province , China (grant no. S201301005689 ), the Science and Technology Program of Guangzhou , China (grant no. 201707010003 ), the Special Foundation of President of Nanfang Hospital, Southern Medical University (grant no. 2016B026 ), and Scientific Research Initiation Programme of Southern Medical University (grant no. CX2018N017 ).
Publisher Copyright:
© 2021
PY - 2022/1
Y1 - 2022/1
N2 - Purpose: To investigate the potential value of inflow-based vascular-space-occupancy (iVASO) MR imaging in differentiating metastatic from inflammatory lymph nodes (LNs). Methods: Ten female New Zealand rabbits with 2.5–3.0 kg body weight were studied. VX2 cells and egg yolk emulsion were inoculated into left and right thighs, respectively, to induce ten metastatic and ten inflammatory popliteal LNs. Conventional MRI and iVASO were performed 2 h prior to, and 10, 20 days after inoculation (D0, D10, D20). The short-axis diameter (S), short- to long-axis diameter ratio (SLR), and arteriolar blood volume (BVa) at each time point and their longitudinal changes of each model were recorded and compared. At D20, all rabbits were sacrificed to perform histological evaluation after the MR scan. Results: The mean values of S, SLR and BVa showed no significant difference between the two groups at D0 (P = 0.987, P = 0.778, P = 0.975). The BVa of the metastatic group was greater than that of the inflammatory at both D10 and D20 (P < 0.05; P < 0.001), whereas the S and SLR of the metastatic group were greater only at D20 (P < 0.001; P = 0.001). Longitudinal analyses showed that the BVa of the metastatic group increased at both D10 and D20 (P = 0.004; P = 0.001), while that of the inflammatory group only increased at D10 (P = 0.024). Conclusion: The BVa measured with iVASO has the potential to detect early metastatic LNs.
AB - Purpose: To investigate the potential value of inflow-based vascular-space-occupancy (iVASO) MR imaging in differentiating metastatic from inflammatory lymph nodes (LNs). Methods: Ten female New Zealand rabbits with 2.5–3.0 kg body weight were studied. VX2 cells and egg yolk emulsion were inoculated into left and right thighs, respectively, to induce ten metastatic and ten inflammatory popliteal LNs. Conventional MRI and iVASO were performed 2 h prior to, and 10, 20 days after inoculation (D0, D10, D20). The short-axis diameter (S), short- to long-axis diameter ratio (SLR), and arteriolar blood volume (BVa) at each time point and their longitudinal changes of each model were recorded and compared. At D20, all rabbits were sacrificed to perform histological evaluation after the MR scan. Results: The mean values of S, SLR and BVa showed no significant difference between the two groups at D0 (P = 0.987, P = 0.778, P = 0.975). The BVa of the metastatic group was greater than that of the inflammatory at both D10 and D20 (P < 0.05; P < 0.001), whereas the S and SLR of the metastatic group were greater only at D20 (P < 0.001; P = 0.001). Longitudinal analyses showed that the BVa of the metastatic group increased at both D10 and D20 (P = 0.004; P = 0.001), while that of the inflammatory group only increased at D10 (P = 0.024). Conclusion: The BVa measured with iVASO has the potential to detect early metastatic LNs.
KW - Animal
KW - Lymph node
KW - Model
KW - Neoplasm
KW - Perfusion magnetic resonance imaging
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U2 - 10.1016/j.mri.2021.10.035
DO - 10.1016/j.mri.2021.10.035
M3 - Article
C2 - 34687849
AN - SCOPUS:85117833131
SN - 0730-725X
VL - 85
SP - 128
EP - 132
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
ER -