Differences in viral load among human respiratory syncytial virus genotypes in hospitalized children with severe acute respiratory infections in the Philippines

Francois Marie Ngako Kadji; Michiko Okamoto; Yuki Furuse; Raita Tamaki; Akira Suzuki; Irene Lirio; Clyde Dapat; Rungnapa Malasao; Mariko Saito; Gay Anne Granada Pedrera-Rico; Veronica Tallo; Socorro Lupisan; Mayuko Saito; Hitoshi Oshitani

doi:10.1186/s12985-016-0565-8

Differences in viral load among human respiratory syncytial virus genotypes in hospitalized children with severe acute respiratory infections in the Philippines

Francois Marie Ngako Kadji, Michiko Okamoto, Yuki Furuse, Raita Tamaki, Akira Suzuki, Irene Lirio, Clyde Dapat, Rungnapa Malasao, Mariko Saito, Gay Anne Granada Pedrera-Rico, Veronica Tallo, Socorro Lupisan, Mayuko Saito, Hitoshi Oshitani

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8 Scopus citations

Abstract

Background: Human respiratory syncytial virus (HRSV) is a leading viral etiologic agent of pediatric lower respiratory infections, including bronchiolitis and pneumonia. Two antigenic subgroups, HRSV-A and B, each contain several genotypes. While viral load may vary among HRSV genotypes and affect the clinical course of disease, data are scarce regarding the actual differences among genotypes. Therefore, this study estimated and compared viral load among NA1 and ON1 genotypes of HRSV-A and BA9 of HRSV-B. ON1 is a newly emerged genotype with a 72-nucleotide duplication in the G gene as observed previously with BA genotypes in HRSV-B. Findings: Children

Original language	English (US)
Article number	565
Journal	Virology Journal
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/s12985-016-0565-8
State	Published - Jun 27 2016
Externally published	Yes

Keywords

Children
Genotype
Pneumonia
Respiratory syncytial virus
Viral load

ASJC Scopus subject areas

Virology
Infectious Diseases

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10.1186/s12985-016-0565-8

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Kadji, F. M. N., Okamoto, M., Furuse, Y., Tamaki, R., Suzuki, A., Lirio, I., Dapat, C., Malasao, R., Saito, M., Pedrera-Rico, G. A. G., Tallo, V., Lupisan, S., Saito, M., & Oshitani, H. (2016). Differences in viral load among human respiratory syncytial virus genotypes in hospitalized children with severe acute respiratory infections in the Philippines. Virology Journal, 13(1), Article 565. https://doi.org/10.1186/s12985-016-0565-8

Kadji, FMN, Okamoto, M, Furuse, Y, Tamaki, R, Suzuki, A, Lirio, I, Dapat, C, Malasao, R, Saito, M, Pedrera-Rico, GAG, Tallo, V, Lupisan, S, Saito, M & Oshitani, H 2016, 'Differences in viral load among human respiratory syncytial virus genotypes in hospitalized children with severe acute respiratory infections in the Philippines', Virology Journal, vol. 13, no. 1, 565. https://doi.org/10.1186/s12985-016-0565-8

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title = "Differences in viral load among human respiratory syncytial virus genotypes in hospitalized children with severe acute respiratory infections in the Philippines",

abstract = "Background: Human respiratory syncytial virus (HRSV) is a leading viral etiologic agent of pediatric lower respiratory infections, including bronchiolitis and pneumonia. Two antigenic subgroups, HRSV-A and B, each contain several genotypes. While viral load may vary among HRSV genotypes and affect the clinical course of disease, data are scarce regarding the actual differences among genotypes. Therefore, this study estimated and compared viral load among NA1 and ON1 genotypes of HRSV-A and BA9 of HRSV-B. ON1 is a newly emerged genotype with a 72-nucleotide duplication in the G gene as observed previously with BA genotypes in HRSV-B. Findings: Children ",

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AU - Kadji, Francois Marie Ngako

AU - Okamoto, Michiko

AU - Furuse, Yuki

AU - Tamaki, Raita

AU - Suzuki, Akira

AU - Lirio, Irene

AU - Dapat, Clyde

AU - Malasao, Rungnapa

AU - Saito, Mariko

AU - Pedrera-Rico, Gay Anne Granada

AU - Tallo, Veronica

AU - Lupisan, Socorro

AU - Saito, Mayuko

AU - Oshitani, Hitoshi

PY - 2016/6/27

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N2 - Background: Human respiratory syncytial virus (HRSV) is a leading viral etiologic agent of pediatric lower respiratory infections, including bronchiolitis and pneumonia. Two antigenic subgroups, HRSV-A and B, each contain several genotypes. While viral load may vary among HRSV genotypes and affect the clinical course of disease, data are scarce regarding the actual differences among genotypes. Therefore, this study estimated and compared viral load among NA1 and ON1 genotypes of HRSV-A and BA9 of HRSV-B. ON1 is a newly emerged genotype with a 72-nucleotide duplication in the G gene as observed previously with BA genotypes in HRSV-B. Findings: Children

AB - Background: Human respiratory syncytial virus (HRSV) is a leading viral etiologic agent of pediatric lower respiratory infections, including bronchiolitis and pneumonia. Two antigenic subgroups, HRSV-A and B, each contain several genotypes. While viral load may vary among HRSV genotypes and affect the clinical course of disease, data are scarce regarding the actual differences among genotypes. Therefore, this study estimated and compared viral load among NA1 and ON1 genotypes of HRSV-A and BA9 of HRSV-B. ON1 is a newly emerged genotype with a 72-nucleotide duplication in the G gene as observed previously with BA genotypes in HRSV-B. Findings: Children

KW - Children

KW - Genotype

KW - Pneumonia

KW - Respiratory syncytial virus

KW - Viral load

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Differences in viral load among human respiratory syncytial virus genotypes in hospitalized children with severe acute respiratory infections in the Philippines

Abstract

Keywords

ASJC Scopus subject areas

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