Differences in quantitative assessment of myocardial scar and gray zone by LGE-CMR imaging using established gray zone protocols

Olurotimi Mesubi, Kelechi Ego-Osuala, Jean Jeudy, James Purtilo, Stephen Synowski, Ameer Abutaleb, Michelle Niekoop, Mohammed Abdulghani, Ramazan Asoglu, Vincent See, Anastasios Saliaris, Stephen Shorofsky, Timm Dickfeld

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) imaging is the gold standard for myocardial scar evaluation. Heterogeneous areas of scar (‘gray zone’), may serve as arrhythmogenic substrate. Various gray zone protocols have been correlated to clinical outcomes and ventricular tachycardia channels. This study assessed the quantitative differences in gray zone and scar core sizes as defined by previously validated signal intensity (SI) threshold algorithms. High quality LGE-CMR images performed in 41 cardiomyopathy patients [ischemic (33) or non-ischemic (8)] were analyzed using previously validated SI threshold methods [Full Width at Half Maximum (FWHM), n-standard deviation (NSD) and modified-FWHM]. Myocardial scar was defined as scar core and gray zone using SI thresholds based on these methods. Scar core, gray zone and total scar sizes were then computed and compared among these models. The median gray zone mass was 2–3 times larger with FWHM (15 g, IQR: 8–26 g) compared to NSD or modified-FWHM (5 g, IQR: 3–9 g; and 8 g. IQR: 6–12 g respectively, p < 0.001). Conversely, infarct core mass was 2.3 times larger with NSD (30 g, IQR: 17–53 g) versus FWHM and modified-FWHM (13 g, IQR: 7–23 g, p < 0.001). The gray zone extent (percentage of total scar that was gray zone) also varied significantly among the three methods, 51 % (IQR: 42–61 %), 17 % (IQR: 11–21 %) versus 38 % (IQR: 33–43 %) for FWHM, NSD and modified-FWHM respectively (p < 0.001). Considerable variability exists among the current methods for MRI defined gray zone and scar core. Infarct core and total myocardial scar mass also differ using these methods. Further evaluation of the most accurate quantification method is needed.

Original languageEnglish (US)
Pages (from-to)359-368
Number of pages10
JournalInternational Journal of Cardiovascular Imaging
Issue number2
StatePublished - Feb 27 2015
Externally publishedYes


  • Cardiac MRI
  • Gray zone
  • Myocardial scar tissue characterization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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