@article{e2bc306dc1b748578a031270f2fb8917,
title = "Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators",
abstract = "Older men sustain excess bone mineral density (BMD) declines after hip fracture; however, BMD provides no information on mechanical structure and strength. The aim was to assess whether changes in hip bone geometry in older men after hip fracture differ than that expected with aging. Two cohorts were used: Baltimore Hip Studies 7th cohort (BHS-7) and Baltimore Men's Osteoporosis Study (MOST). The sample (N = 170) included older Caucasian men with hip fracture that were propensity score matched (1:1) to community-dwelling non-fractured comparators. Hip Structural Analysis (HSA) calculated aerial BMD and metrics of bone structural strength: cross-sectional bone area (CSA), cortical outer diameter (OD), section modulus (SM), and centroid position (CP). Mixed-effect models estimated changes in HSA parameters and adjusted robust regression models evaluated between-cohort differences in annual percent change at the narrow neck (NN), intertrochanteric (IT), and femoral shaft (FS). Hip fracture was associated with statistically greater declines in NN CSA (β = −2.818; 95% CI: −3.300%, −2.336%), SM (β = −1.896%; 95% CI: −2.711%, −1.080%) and CP (β = −0.884%; 95% CI: −0.889%, −0.880%) and significantly larger increases in NN OD (β = 0.187%; 95% CI: 0.185%, 0.190%). Differences in IT HSA parameters were like the NN but larger in magnitude, while there were favorable changes in FS geometry where fragility fractures are rare. Findings indicate there are declines in bone structure and strength at the NN and IT regions of the proximal femur in older men during hip fracture recovery that far exceed what occurs during normal aging.",
keywords = "Aging, DXA, Fracture prevention, Injury/fracture healing, Osteoporosis",
author = "Rathbun, {Alan M.} and Jay Magaziner and Shardell, {Michelle D.} and Beck, {Thomas J.} and Yerges-Armstrong, {Laura M.} and Denise Orwig and Hicks, {Gregory E.} and Ryan, {Alice S.} and Hochberg, {Marc C.}",
note = "Funding Information: This material is based on upon work supported (or supported in part) by the Department of Veterans Affairs , VHA Office of Research and Development , VA Maryland Health Care System , and Baltimore VA Medical Center . The authors would like to thank the facilities, orthopedic surgeons, and hospital personnel; Baltimore Hip Studies research staff; and participants for volunteering their time and information for this work. Funding Information: This work was supported by grants from the National Institute on Aging (K01 AG064041, R37 AG009901, R01 AG029315, P30 AG028747, and R01 AG048069) and the Rheumatology Research Foundation. The funding sponsor had no role in study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the article for publication.This material is based on upon work supported (or supported in part) by the Department of Veterans Affairs, VHA Office of Research and Development, VA Maryland Health Care System, and Baltimore VA Medical Center. The authors would like to thank the facilities, orthopedic surgeons, and hospital personnel; Baltimore Hip Studies research staff; and participants for volunteering their time and information for this work. Funding Information: This work was supported by grants from the National Institute on Aging ( K01 AG064041 , R37 AG009901 , R01 AG029315 , P30 AG028747 , and R01 AG048069 ) and the Rheumatology Research Foundation . The funding sponsor had no role in study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the article for publication. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2020",
month = mar,
doi = "10.1016/j.bone.2019.115187",
language = "English (US)",
volume = "132",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier Inc.",
}