Diethylstilbestrol (DES)-induced clear cell adenocarcinoma of the vagina metastasizing to the brain

Li Mei Lin, Daniel M. Sciubba, Gary L. Gallia, Jeffrey Sosnowski, Jon D. Weingart

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background.: Primary vaginal clear cell adenocarcinoma (CCA) is a rare gynecological malignancy occurring predominantly in young females with a history of diethylstilbestrol exposure in utero. Vaginal CCA commonly metastasizes to the lungs and the supraclavicular lymph nodes; however we present a rare case of diethylstilbestrol-induced vaginal CCA with cerebral metastases. Case description.: A 43-year-old woman with prenatal diethylstilbestrol exposure and history of vaginal CCA treatment 8 years prior to current presentation noted new onset headache and dizziness. MRI showed an enhancing mass in the right frontal lobe. Histopathology was consistent with CCA. Conclusions.: This case report highlights the necessity of close extended follow-up in patients with a history of vaginal CCA and demonstrates the potential for spread of primary vaginal CCA to the brain.

Original languageEnglish (US)
Pages (from-to)273-276
Number of pages4
JournalGynecologic oncology
Issue number1
StatePublished - Apr 2007


  • Brain metastasis
  • Clear cell adenocarcinoma
  • DES
  • Diethylstilbestrol
  • Vaginal cancer

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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