TY - JOUR
T1 - Dietary Total Antioxidant Capacity and Cardiovascular Disease Risk Factors
T2 - A Systematic Review of Observational Studies
AU - Mozaffari, Hadis
AU - Daneshzad, Elnaz
AU - Surkan, Pamela J.
AU - Azadbakht, Leila
N1 - Funding Information:
This study was funded by Iran National Science Foundation (grant number 96003297).
Publisher Copyright:
© 2018, © 2018 American College of Nutrition.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/8/18
Y1 - 2018/8/18
N2 - Objective: Measurement of dietary total antioxidant capacity (DTAC) is considered a new holistic dietary approach and assesses total antioxidants present in the overall diet. Our aim was to perform a comprehensive review of the literature on the association between DTAC and cardiovascular disease (CVD) risk factors. Methods: PubMed, Web of Science, and Scopus were used to conduct a comprehensive search for articles published on this topic through September 2017. There was no limit on earliest year of publication. The search was based on the following keywords: dietary total antioxidant capacity, nonenzymatic antioxidant capacity, total radical-trapping antioxidant parameter, ferric reducing ability of plasma, oxygen radical absorbance capacity, Trolox equivalent antioxidant capacity, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), total cholesterol (TC), waist circumference (WC), insulin resistance, homeostatic model assessment of insulin resistance (HOMA-IR), insulin, obesity, glucose, C-reactive protein (CRP), blood pressure (BP), and body mass index. In total, 16 papers were identified for inclusion in the present systematic review. Results: Most well-designed studies that evaluated associations between DTAC and CVD risk factors showed inverse associations for fasting blood glucose, CRP, BP, and WC and positive associations for HDL-C. However, there was no association between DTAC and LDL-C or TC in any of the studies. Results regarding the association of DTAC with insulin, HOMA-IR, high-sensitivity CRP, and TG in the published literature were inconsistent. Conclusions: Findings indicated a substantial association between high DTAC and most CVD-related risk factors.
AB - Objective: Measurement of dietary total antioxidant capacity (DTAC) is considered a new holistic dietary approach and assesses total antioxidants present in the overall diet. Our aim was to perform a comprehensive review of the literature on the association between DTAC and cardiovascular disease (CVD) risk factors. Methods: PubMed, Web of Science, and Scopus were used to conduct a comprehensive search for articles published on this topic through September 2017. There was no limit on earliest year of publication. The search was based on the following keywords: dietary total antioxidant capacity, nonenzymatic antioxidant capacity, total radical-trapping antioxidant parameter, ferric reducing ability of plasma, oxygen radical absorbance capacity, Trolox equivalent antioxidant capacity, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), total cholesterol (TC), waist circumference (WC), insulin resistance, homeostatic model assessment of insulin resistance (HOMA-IR), insulin, obesity, glucose, C-reactive protein (CRP), blood pressure (BP), and body mass index. In total, 16 papers were identified for inclusion in the present systematic review. Results: Most well-designed studies that evaluated associations between DTAC and CVD risk factors showed inverse associations for fasting blood glucose, CRP, BP, and WC and positive associations for HDL-C. However, there was no association between DTAC and LDL-C or TC in any of the studies. Results regarding the association of DTAC with insulin, HOMA-IR, high-sensitivity CRP, and TG in the published literature were inconsistent. Conclusions: Findings indicated a substantial association between high DTAC and most CVD-related risk factors.
KW - Dietary total antioxidant capacity
KW - blood pressure
KW - cardiovascular disease
KW - cholesterol
KW - insulin resistance
KW - systematic review
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U2 - 10.1080/07315724.2018.1441079
DO - 10.1080/07315724.2018.1441079
M3 - Review article
C2 - 29714643
AN - SCOPUS:85050523893
SN - 0731-5724
VL - 37
SP - 533
EP - 545
JO - Journal of the American College of Nutrition
JF - Journal of the American College of Nutrition
IS - 6
ER -