Dietary Total Antioxidant Capacity and Cardiovascular Disease Risk Factors: A Systematic Review of Observational Studies

Hadis Mozaffari, Elnaz Daneshzad, Pamela J. Surkan, Leila Azadbakht

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Objective: Measurement of dietary total antioxidant capacity (DTAC) is considered a new holistic dietary approach and assesses total antioxidants present in the overall diet. Our aim was to perform a comprehensive review of the literature on the association between DTAC and cardiovascular disease (CVD) risk factors. Methods: PubMed, Web of Science, and Scopus were used to conduct a comprehensive search for articles published on this topic through September 2017. There was no limit on earliest year of publication. The search was based on the following keywords: dietary total antioxidant capacity, nonenzymatic antioxidant capacity, total radical-trapping antioxidant parameter, ferric reducing ability of plasma, oxygen radical absorbance capacity, Trolox equivalent antioxidant capacity, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), total cholesterol (TC), waist circumference (WC), insulin resistance, homeostatic model assessment of insulin resistance (HOMA-IR), insulin, obesity, glucose, C-reactive protein (CRP), blood pressure (BP), and body mass index. In total, 16 papers were identified for inclusion in the present systematic review. Results: Most well-designed studies that evaluated associations between DTAC and CVD risk factors showed inverse associations for fasting blood glucose, CRP, BP, and WC and positive associations for HDL-C. However, there was no association between DTAC and LDL-C or TC in any of the studies. Results regarding the association of DTAC with insulin, HOMA-IR, high-sensitivity CRP, and TG in the published literature were inconsistent. Conclusions: Findings indicated a substantial association between high DTAC and most CVD-related risk factors.

Original languageEnglish (US)
Pages (from-to)533-545
Number of pages13
JournalJournal of the American College of Nutrition
Issue number6
StatePublished - Aug 18 2018


  • Dietary total antioxidant capacity
  • blood pressure
  • cardiovascular disease
  • cholesterol
  • insulin resistance
  • systematic review

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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