TY - JOUR
T1 - Dietary flavonoids and respiratory diseases
T2 - A population-based multi-case-control study in Italian adults
AU - Mattioli, Veronica
AU - Zanolin, Maria Elisabetta
AU - Cazzoletti, Lucia
AU - Bono, Roberto
AU - Cerveri, Isa
AU - Ferrari, Marcello
AU - Pirina, Pietro
AU - Garcia-Larsen, Vanessa
N1 - Funding Information:
Acknowledgements: The authors are indebted to all the individuals of the GEIRD study for their participation. Financial support: The GEIRD project was funded by the Cariverona Foundation; the Italian Ministry of Health; Chiesi Farmaceutici; and the Italian Medicines Agency (AIFA). The funders had no role in the design; in the collection, analysis and interpretation of the data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. Conflict of interest: The authors declare no conflict of interest. Authorship: V.G.-L., M.E.Z. and L.C. conceived and designed the study. L.C., M.E.Z., R.B., I.C., P.P. and M.F. contributed to the data collection. V.M. performed the statistical analysis. L.C., M.E.Z. and V.M. drafted the manuscript. L.C., M.E.Z., V.G.-L., A.G., V.M., P.P. and M.F. contributed to the interpretation of data, revised the paper critically for important intellectual content and approved the version to be published. Ethics of human subject participation: This study was conducted according to the guidelines laid down in the Declaration of Helsinki and all procedures involving human subjects were approved by the ethics committee of Azienda Ospedaliera of Verona, as coordinating centre. Written informed consent was obtained from all subjects.
Publisher Copyright:
© 2020 Cambridge University Press. All rights reserved.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Objective: To analyse the associations between chronic respiratory diseases and intakes of total flavonoids and their major subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, polymers and proanthocyanidins).Design: Multi-case-control study.Setting: The analysis was conducted in the frame of the Genes Environment Interaction in Respiratory Diseases (GEIRD) study. The European Prospective Investigation into Cancer and Nutrition FFQ was used to ascertain dietary intake. Multinomial regression models adjusting for age, sex, centre, BMI, smoking habit, alcohol intake, education, total energy intake, vitamin C intake and total fruit intake were used to examine the associations between dietary exposures and the relative risk ratio (RRR) of being a case.Participants: Individuals (n 990) hierarchically defined as follows: cases with asthma (current, n 159; past, n 78), chronic bronchitis (n 47), rhinitis (allergic rhinitis, n 167; non-Allergic rhinitis, n 142) and controls (n 97).Results: An increase of 1 sd in flavanones was associated with a reduced risk of non-Allergic rhinitis (adjusted RRR = 0·68, 95 % CI 0·47, 0·97); a similar result was found comparing the highest v. lowest quartile of flavanones intake (adjusted RRR = 0·24, 95 % CI 0·10, 0·59).Conclusions: Flavonoids contained in fruits and vegetables, especially flavanones, might reduce the risk of non-Allergic rhinitis. No associations were found between other flavonoids and the considered outcomes.
AB - Objective: To analyse the associations between chronic respiratory diseases and intakes of total flavonoids and their major subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, polymers and proanthocyanidins).Design: Multi-case-control study.Setting: The analysis was conducted in the frame of the Genes Environment Interaction in Respiratory Diseases (GEIRD) study. The European Prospective Investigation into Cancer and Nutrition FFQ was used to ascertain dietary intake. Multinomial regression models adjusting for age, sex, centre, BMI, smoking habit, alcohol intake, education, total energy intake, vitamin C intake and total fruit intake were used to examine the associations between dietary exposures and the relative risk ratio (RRR) of being a case.Participants: Individuals (n 990) hierarchically defined as follows: cases with asthma (current, n 159; past, n 78), chronic bronchitis (n 47), rhinitis (allergic rhinitis, n 167; non-Allergic rhinitis, n 142) and controls (n 97).Results: An increase of 1 sd in flavanones was associated with a reduced risk of non-Allergic rhinitis (adjusted RRR = 0·68, 95 % CI 0·47, 0·97); a similar result was found comparing the highest v. lowest quartile of flavanones intake (adjusted RRR = 0·24, 95 % CI 0·10, 0·59).Conclusions: Flavonoids contained in fruits and vegetables, especially flavanones, might reduce the risk of non-Allergic rhinitis. No associations were found between other flavonoids and the considered outcomes.
KW - Asthma
KW - Chronic bronchitis
KW - Flavonoids
KW - Rhinitis
UR - https://www.scopus.com/pages/publications/85078884144
UR - https://www.scopus.com/pages/publications/85078884144#tab=citedBy
U2 - 10.1017/S1368980019003562
DO - 10.1017/S1368980019003562
M3 - Article
C2 - 31996276
AN - SCOPUS:85078884144
SN - 1368-9800
VL - 23
SP - 2548
EP - 2556
JO - Public health nutrition
JF - Public health nutrition
IS - 14
ER -