Abstract
Background: The V.A.C.®System has become a popular device for the treatment of a variety of complex tissue defects, often based on empirical data. The objective of this study was to optimize the kinetics of V.A.C.® application and to test the impact of foam pore size. Methods: The parameters (waveform and pore size) were modified in the therapy of full-thickness wounds in diabetic mice. Wound closure and tissue response were quantitatively evaluated by macroscopic, histological and immunohistochemical analyses. Results: The continuous and sinusoidal waveform treatment induced the highest cellular proliferation rates, angiogenesis and granulation tissue depth compared to controls. Wound bed deformation was proportionally higher with the foam pore size, correlated with greater thickness of granulation tissue. Conclusions: The physical modulation has a significant impact in wound healing, while waveform modulation only causes a minor modulatory effect on granulation tissue formation, angiogenesis and proliferation in our diabetic mouse model.
| Translated title of the contribution | Waveform and foam pore size optimization of the vacuum assisted closure device |
|---|---|
| Original language | German |
| Pages (from-to) | 12-16 |
| Number of pages | 5 |
| Journal | Zeitschrift fur Wundheilung |
| Volume | 15 |
| Issue number | A |
| State | Published - Jun 8 2010 |
Keywords
- Murine model
- Pore size
- V.A.C.® therapy
- Waveform
ASJC Scopus subject areas
- Surgery
- Dermatology
- Nursing (miscellaneous)