Dichloromethotrexate - A critical reassessment

P. J. O'Dwyer, B. Leyland-Jones, M. T. Alonso, M. Eisenberger, D. F. Hoth

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


We review the biochemical, pharmacologic, and clinical evidence, which indicates that dichloromethotrexate (DCMTX) may in certain circumstances display a therapeutic advantage over the parent compound methotrexate (MTX); studies are suggested to clarify the role of DCMTX in the clinic.

Original languageEnglish (US)
Pages (from-to)1148-1153
Number of pages6
JournalJournal of Clinical Oncology
Issue number8
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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