TY - JOUR
T1 - Dibutyryl Cyclic Adenosine 3′,5′-Monophosphate
T2 - Its Role in Regulation of Cat Brain Extracellular Fluid
AU - Aarabi, Bizhan
AU - Epstein, Mel H.
AU - Long, Donlin M.
PY - 1979/8
Y1 - 1979/8
N2 - The role of dibutyryl cyclic adenosine 3′,5′-monophosphate (db cAMP) in influencing the water content of the cat's gray and white matter was evaluated by intracortical injection of 20 μL of 2 × 10-1 to 2 × 10-6M solution of db cAMP. Cholera toxin, a stimulator of adenylate cyclase, also was tested. Concentrations of db cAMP less than 10-3M failed to produce significant change in brain water content, while concentrations greater than 10-2M produced 31.5% ± 8% and 17.3% ± 3.6% increases in white matter volume, respectively (P γ.05). Cholera toxin did not increase brain water levels. These results are discussed in relation to the pathophysiology of brain edema.
AB - The role of dibutyryl cyclic adenosine 3′,5′-monophosphate (db cAMP) in influencing the water content of the cat's gray and white matter was evaluated by intracortical injection of 20 μL of 2 × 10-1 to 2 × 10-6M solution of db cAMP. Cholera toxin, a stimulator of adenylate cyclase, also was tested. Concentrations of db cAMP less than 10-3M failed to produce significant change in brain water content, while concentrations greater than 10-2M produced 31.5% ± 8% and 17.3% ± 3.6% increases in white matter volume, respectively (P γ.05). Cholera toxin did not increase brain water levels. These results are discussed in relation to the pathophysiology of brain edema.
UR - http://www.scopus.com/inward/record.url?scp=0018393361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018393361&partnerID=8YFLogxK
U2 - 10.1001/archneur.1979.00500440068012
DO - 10.1001/archneur.1979.00500440068012
M3 - Article
C2 - 228644
AN - SCOPUS:0018393361
SN - 0003-9942
VL - 36
SP - 498
EP - 500
JO - Archives of neurology
JF - Archives of neurology
IS - 8
ER -