The role of dibutyryl cyclic adenosine 3′,5′-monophosphate (db cAMP) in influencing the water content of the cat's gray and white matter was evaluated by intracortical injection of 20 μL of 2 × 10-1 to 2 × 10-6M solution of db cAMP. Cholera toxin, a stimulator of adenylate cyclase, also was tested. Concentrations of db cAMP less than 10-3M failed to produce significant change in brain water content, while concentrations greater than 10-2M produced 31.5% ± 8% and 17.3% ± 3.6% increases in white matter volume, respectively (P γ.05). Cholera toxin did not increase brain water levels. These results are discussed in relation to the pathophysiology of brain edema.
|Original language||English (US)|
|Number of pages||3|
|Journal||Archives of neurology|
|State||Published - Aug 1979|
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology