@article{4fbdae840c01433ab8a5220c771b778c,
title = "Diastolic Function and Ambulatory Hypertension in Children With Chronic Kidney Disease",
abstract = "Diastolic dysfunction is one of the earliest cardiac abnormalities in patients with chronic kidney disease. We analyzed echocardiographic markers of left ventricular function from 786 children and adolescents (1658 person-visits) enrolled in the CKiD (Chronic Kidney Disease in Children) cohort, a large prospective observational study of children with chronic kidney disease. Primary outcome was early mitral inflow velocity-to-early mitral annular peak velocity (E/e′) ratio as a marker of left ventricular compliance. Abnormal diastolic function was defined as E/e′>8.0. Those with an abnormal E/e′ ratio were younger, had a lower estimated glomerular filtration rate and hemoglobin, and a higher prevalence of hypertension and left ventricular hypertrophy compared to children with a normal E/e′. In adjusted analysis, a higher E/e′ ratio was independently associated with ambulatory (sustained) hypertension (1.66 [95% CI, 1.15-2.42]). Other significant independent predictors were higher left ventricular mass index Z score, increased body mass index Z score, lower hemoglobin, higher phosphorus level, and younger age. Casual blood pressure was not significantly associated with higher E/e′. These data indicate that ambulatory blood pressure might better identify children with chronic kidney disease at risk for subclinical cardiac dysfunction than clinic blood pressure alone.",
keywords = "blood pressure, cardiovascular disease, glomerular filtration rate, heart, hypertrophy",
author = "Mitsnefes, {Mark M.} and Yunwen Xu and Ng, {Derek K.} and Garick Hill and Thomas Kimball and Furth, {Susan L.} and Warady, {Bradley A.}",
note = "Funding Information: Data in this manuscript were collected by the CKiD (Chronic Kidney Disease in Children) prospective cohort study with clinical coordinating centers (Principal Investigators) at Children's Mercy Hospital and the University of Missouri-Kansas City (B.A. Warady) and Children's Hospital of Philadelphia (S.L. Furth), Central Biochemistry Laboratory (George Schwartz, MD) at the University of Rochester Medical Center, and data coordinating center (Alvaro Mu{\~n}oz and D.K. Ng) at the Johns Hopkins Bloomberg School of Public Health. The CKiD Study is supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases, with additional funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Heart, Lung, and Blood Institute (U01 DK066143, U01 DK066174, U24 DK082194, U24 DK066116). The CKiD website is located at https://statepi.jhsph.edu/ckid and a list of CKiD collaborators can be found at https://statepi.jhsph.edu/ckid/ site-investigators/. Funding Information: Data in this manuscript were collected by the CKiD (Chronic Kidney Disease in Children) prospective cohort study with clinical coordinating centers (Principal Investigators) at Children{\textquoteright}s Mercy Hospital and the University of Missouri–Kansas City (B.A. Warady) and Children{\textquoteright}s Hospital of Philadelphia (S.L. Furth), Central Biochemistry Laboratory (George Schwartz, MD) at the University of Rochester Medical Center, and data coordinating center (Alvaro Mu{\~n}oz and D.K. Ng) at the Johns Hopkins Bloomberg School of Public Health. The CKiD Study is supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases, with additional funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Heart, Lung, and Blood Institute (U01 DK066143, U01 DK066174, U24 DK082194, U24 DK066116). The CKiD website is located at https://statepi.jhsph.edu/ckid and a list of CKiD collaborators can be found at https://statepi.jhsph.edu/ckid/site-investigators/ . Publisher Copyright: {\textcopyright} 2021 American Heart Association, Inc.",
year = "2021",
month = nov,
day = "1",
doi = "10.1161/HYPERTENSIONAHA.121.17449",
language = "English (US)",
volume = "78",
pages = "1347--1354",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "5",
}