TY - JOUR
T1 - Diagnostic performance of gadobenate dimeglumine-enhanced MR angiography of the iliofemoral and calf arteries
T2 - A large-scale multicenter trial
AU - Thurnher, Siegfried
AU - Miller, Stephan
AU - Schneider, Günther
AU - Ballarati, Claudio
AU - Bongartz, Georg
AU - Herborn, Christoph U.
AU - Schoenberg, Stefan
AU - Cova, Maria Assunta
AU - Morana, Giovanni
AU - Niazi, Khusrow
AU - Iezzi, Roberto
AU - Taupitz, Matthias
AU - Bluemke, David A.
AU - Kreitner, Karl Friedrich
AU - Kirchin, Miles A.
AU - Pirovano, Gianpaolo
PY - 2007/11
Y1 - 2007/11
N2 - OBJECTIVE. The purpose of this study was to compare gadobenate dimeglumine-enhanced MR angiography and unenhanced time-of-flight MR angiography for the detection of significant peripheral arterial occlusive disease using digital subtraction angiography as our reference standard. SUBJECTS AND METHODS. Two hundred seventy-two patients underwent MR angiography and digital subtraction angiography of the iliofemoral arteries. MR angiography was performed before (2D time-of-flight acquisitions) and after (spoiled gradient-echo acquisitions) the administration of 0.1 mmol/kg of gadobenate dimeglumine at 1-2 mL/s. Contrast-enhanced MR angiography and digital subtraction angiography of the calf arteries were performed in 241 of 272 participants. Images were evaluated on-site and by four blinded reviewers (three for MR angiography, one for digital subtraction angiography). Comparative diagnostic performance for the detection of significant (≥ 51% vessel lumen narrowing) disease was evaluated using the McNemar test and generalized estimating equations. Interobserver agreement was assessed with generalized kappa statistics. The chi-square test was used to compare technical failure rates. RESULTS. Digital subtraction angiography confirmed significant disease (597 stenoses, 386 occlusions) in 983 iliofemoral segments. The sensitivity (54-80.9%), specificity (89.7-95.3%), and accuracy (85-87.5%) of contrast-enhanced MR angiography for the detection of significant iliofemoral disease were significantly (p < 0.001, all reviewers) better than those of time-of-flight MR angiography (33.2-62.8%, 74.3-88.9%, and 68-77.3%, respectively). Similar diagnostic performance was obtained for the calf arteries. The technical failure rate with contrast-enhanced MR angiography (2.5-3.4%) was similar to that of digital subtraction angiography (1.4%) and significantly (p < 0.001) lower than that of time-of-flight MR angiography (6.2-18.0%). Significantly better reproducibility (p < 0.001) was obtained with contrast-enhanced MR angiography (82% vs 65.2% agreement; κ = 0.66 vs 0.45). CONCLUSION. Improved diagnostic performance and reproducibility ate achievable with gadobenate dimeglumine-enhanced MR angiography in patients with peripheral arterial occlusive disease.
AB - OBJECTIVE. The purpose of this study was to compare gadobenate dimeglumine-enhanced MR angiography and unenhanced time-of-flight MR angiography for the detection of significant peripheral arterial occlusive disease using digital subtraction angiography as our reference standard. SUBJECTS AND METHODS. Two hundred seventy-two patients underwent MR angiography and digital subtraction angiography of the iliofemoral arteries. MR angiography was performed before (2D time-of-flight acquisitions) and after (spoiled gradient-echo acquisitions) the administration of 0.1 mmol/kg of gadobenate dimeglumine at 1-2 mL/s. Contrast-enhanced MR angiography and digital subtraction angiography of the calf arteries were performed in 241 of 272 participants. Images were evaluated on-site and by four blinded reviewers (three for MR angiography, one for digital subtraction angiography). Comparative diagnostic performance for the detection of significant (≥ 51% vessel lumen narrowing) disease was evaluated using the McNemar test and generalized estimating equations. Interobserver agreement was assessed with generalized kappa statistics. The chi-square test was used to compare technical failure rates. RESULTS. Digital subtraction angiography confirmed significant disease (597 stenoses, 386 occlusions) in 983 iliofemoral segments. The sensitivity (54-80.9%), specificity (89.7-95.3%), and accuracy (85-87.5%) of contrast-enhanced MR angiography for the detection of significant iliofemoral disease were significantly (p < 0.001, all reviewers) better than those of time-of-flight MR angiography (33.2-62.8%, 74.3-88.9%, and 68-77.3%, respectively). Similar diagnostic performance was obtained for the calf arteries. The technical failure rate with contrast-enhanced MR angiography (2.5-3.4%) was similar to that of digital subtraction angiography (1.4%) and significantly (p < 0.001) lower than that of time-of-flight MR angiography (6.2-18.0%). Significantly better reproducibility (p < 0.001) was obtained with contrast-enhanced MR angiography (82% vs 65.2% agreement; κ = 0.66 vs 0.45). CONCLUSION. Improved diagnostic performance and reproducibility ate achievable with gadobenate dimeglumine-enhanced MR angiography in patients with peripheral arterial occlusive disease.
KW - Contrast agents
KW - Diagnostic performance
KW - Gadobenate dimeglumine
KW - MR angiography
KW - Peripheral arterial occlusive disease
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U2 - 10.2214/AJR.07.2218
DO - 10.2214/AJR.07.2218
M3 - Article
C2 - 17954665
AN - SCOPUS:35649021275
SN - 0361-803X
VL - 189
SP - 1223
EP - 1237
JO - American Journal of Roentgenology
JF - American Journal of Roentgenology
IS - 5
ER -