TY - JOUR
T1 - Diagnostic criteria for the neuropathological assessment of Alzheimer's disease
T2 - Current status and major issues
AU - Wisniewski, H. M.
AU - Silverman, W.
N1 - Funding Information:
We thank Drs. Nicole Schupf, Jerzy Wegiel, and Warren Zigman for their valuable comments on earlier drafts of the manuscript. Work described in this paper was supported in part by funds provided by the state of New York through its Office of Mental Retardation and Developmental Disabilities, as well as by Grants PO1 AGO4220 and PO1 AG11531 from the National Institute on Aging.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1997
Y1 - 1997
N2 - A Consensus Conference focusing on Alzheimer's disease (AD) took place in November 1996 to recommend uniform evaluation procedures and diagnostic criteria, co-sponsored by the National Institute on Aging and the Reagan Institute of the Alzheimer's Association. In conjunction with this conference, we reviewed diagnostic practices in current use, together with various neuropathological criteria proposed since 1985. Difficulties were identified in developing 'gold standard' criteria for diagnosis and case classification of AD based upon the current state of knowledge. Working criteria for use within research contexts were proposed that acknowledged the realities of scientific limitations by inclusion of a broad and heterogeneous category of 'uncertain' cases. (Eventually, methods will be developed for identifying these cases as preclinical AD, dementia due to multiple causes or non-AD, but this is not now possible.) Within applied contexts, the use of CERAD guidelines was supported. Finally, recommendations generated at the Consensus Conference were discussed, emphasizing the rapid pace of recent scientific advancement and the need for ongoing empirical reevaluation and modification of the Group's proposal.
AB - A Consensus Conference focusing on Alzheimer's disease (AD) took place in November 1996 to recommend uniform evaluation procedures and diagnostic criteria, co-sponsored by the National Institute on Aging and the Reagan Institute of the Alzheimer's Association. In conjunction with this conference, we reviewed diagnostic practices in current use, together with various neuropathological criteria proposed since 1985. Difficulties were identified in developing 'gold standard' criteria for diagnosis and case classification of AD based upon the current state of knowledge. Working criteria for use within research contexts were proposed that acknowledged the realities of scientific limitations by inclusion of a broad and heterogeneous category of 'uncertain' cases. (Eventually, methods will be developed for identifying these cases as preclinical AD, dementia due to multiple causes or non-AD, but this is not now possible.) Within applied contexts, the use of CERAD guidelines was supported. Finally, recommendations generated at the Consensus Conference were discussed, emphasizing the rapid pace of recent scientific advancement and the need for ongoing empirical reevaluation and modification of the Group's proposal.
KW - Alzheimer's disease
KW - Diagnosis
KW - Neurofibrillary pathology
KW - Neuropathology
KW - β-Amyloid pathology
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U2 - 10.1016/S0197-4580(97)00068-7
DO - 10.1016/S0197-4580(97)00068-7
M3 - Article
C2 - 9330984
AN - SCOPUS:0030713295
SN - 0197-4580
VL - 18
SP - S43-S50
JO - Neurobiology of aging
JF - Neurobiology of aging
IS - 4 SUPPL.
ER -