TY - JOUR
T1 - Diagnostic coronary angiography induces a systemic inflammatory response in patients with stable angina
AU - Goldberg, Alexander
AU - Zinder, Oren
AU - Zdorovyak, Alexander
AU - Diamond, Eric
AU - Lischinsky, Sophie
AU - Gruberg, Luis
AU - Markiewicz, Walter
AU - Beyar, Rafael
AU - Aronson, Doron
PY - 2003/11
Y1 - 2003/11
N2 - Background: Systemic markers of inflammation increase after percutaneous coronary intervention (PCI). The rise in inflammatory markers after PCI is frequently attributed to the inflammatory stimulus associated with coronary artery injury during balloon inflation and coronary stent implantation. The aim of this study was the determine whether diagnostic coronary angiography performed in patients with stable angina triggers a systemic inflammatory response. Methods: We prospectively studied patients with chronic stable angina undergoing either coronary angiography (n = 13) or coronary angiography followed by PCI (n = 13). Peripheral blood samples were obtained before and 24 hours, 48 hours, and 4 weeks after the procedure and analyzed for C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). Patients with periprocedural myocardial necrosis were excluded. Results: There was a significant increase in CRP levels at 24 and 48 hours in both the coronary angiography (P
AB - Background: Systemic markers of inflammation increase after percutaneous coronary intervention (PCI). The rise in inflammatory markers after PCI is frequently attributed to the inflammatory stimulus associated with coronary artery injury during balloon inflation and coronary stent implantation. The aim of this study was the determine whether diagnostic coronary angiography performed in patients with stable angina triggers a systemic inflammatory response. Methods: We prospectively studied patients with chronic stable angina undergoing either coronary angiography (n = 13) or coronary angiography followed by PCI (n = 13). Peripheral blood samples were obtained before and 24 hours, 48 hours, and 4 weeks after the procedure and analyzed for C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). Patients with periprocedural myocardial necrosis were excluded. Results: There was a significant increase in CRP levels at 24 and 48 hours in both the coronary angiography (P
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U2 - 10.1016/S0002-8703(03)00407-1
DO - 10.1016/S0002-8703(03)00407-1
M3 - Article
C2 - 14597930
AN - SCOPUS:0242636428
SN - 0002-8703
VL - 146
SP - 819
EP - 823
JO - American Heart Journal
JF - American Heart Journal
IS - 5
ER -