@article{c9f4d482861e4b3c9fea5931a68feb30,
title = "Diagnostic ability of retinal nerve fiber layer imaging by swept-source optical coherence tomography in glaucoma",
abstract = "Purpose To evaluate the diagnostic accuracies of swept-source optical coherence tomography (OCT) wide-angle and peripapillary retinal nerve fiber layer (RNFL) thickness measurements for glaucoma detection. Design Cross-sectional case-control study. Methods In this study we enrolled 144 glaucomatous eyes of 106 subjects and 66 eyes of 42 healthy subjects from the Diagnostic Innovations in Glaucoma Study. Glaucoma was defined by the presence of repeatable abnormal standard automated perimetry results and/or progressive glaucomatous optic disc change on masked grading of stereophotographs. Wide-angle and peripapillary RNFL thicknesses were assessed using swept-source OCT. Peripapillary RNFL thickness was also evaluated using spectral-domain OCT. Areas under the receiver operating characteristic (ROC) curves were calculated to evaluate the ability of the different swept-source OCT and spectral-domain OCT parameters to discriminate between glaucomatous and healthy eyes. Results Mean (±standard deviation) average spectral-domain OCT wide-angle RNFL thicknesses were 50.5 ± 5.8 μm and 35.0 ± 9.6 μm in healthy and glaucomatous eyes, respectively (P < 0.001). Corresponding values for swept-source OCT peripapillary RNFL thicknesses were 103.5 ± 12.3 μm and 72.9 ± 16.5 μm, respectively (P < 0.001). Areas under the ROC curves of swept-source OCT wide-angle and peripapillary RNFL thickness were 0.88 and 0.89, respectively. Swept-source OCT performed similar to average peripapillary RNFL thickness obtained by spectral-domain OCT (area under the ROC curve of 0.90). Conclusion Swept-source OCT wide-angle and peripapillary RNFL thickness measurements performed well for detecting glaucomatous damage. The diagnostic accuracies of the swept-source OCT and spectral-domain OCT RNFL imaging protocols evaluated in this study were similar.",
author = "Zhiyong Yang and Tatham, {Andrew J.} and Zangwill, {Linda M.} and Weinreb, {Robert N.} and Chunwei Zhang and Medeiros, {Felipe A.}",
note = "Funding Information: All authors have completed and submitted the ICMJE form for disclosure of potential conflicts of interest, and the following were reported. Drs Zangwill, Weinreb and Medeiros receive research support from Carl-Zeiss Meditec (Dublin, California); Heidelberg Engineering (Heidelberg, Germany); and Topcon (Tokyo, Japan). Dr Weinreb receives resource support from Optovue (Fremont, California). Drs Medeiros and Weinreb are consultants to Carl-Zeiss Meditec. Dr Weinreb is a consultant to Topcon, Inc. Dr Medeiros has received research support from Topcon, Inc. Drs. Yang, Tatham and Zhang have no financial disclosures. Supported in part by National Institutes of Health/National Eye Institute grants EY021818 (F.A.M.); EY11008 (L.M.Z.); EY14267 (L.M.Z.); EY019869 (L.M.Z.); core grant P30EY022589 , National Institutes of Health at Bethesda, Maryland; grants for participants' glaucoma medications from Alcon (Forth Worth, Texas); Allergan (Irvine, California); Pfizer (New York, New York); Merck (Whitehouse Station, New Jersey); Santen (Osaka, Japan); Natural Science Foundation of Heilongjiang Province for Returned Scholars (Beijing, China) (No. LC2012C21 (C.Z.); innovation research special fund of the Science and Technology of Heilong Jiang Province (Harbin, China), No. 2011RFLYS029 (C.Z.); Scientific and technical research fund of Education Bureau of Heilongjiang Province (Harbin, China), No. 12511311 (C.Z.); and an unrestricted grant from Research to Prevent Blindness (New York, New York). Involved in Design and conduct of study (Z.Y., A.J.T., C.Z., R.N.W., L.M.Z., F.A.M.); Collection, management, analysis, and interpretation of data (Z.Y., A.J.T., C.Z., R.N.W., L.M.Z., F.A.M.); and Preparation, review, or approval of manuscript (Z.Y., A.J.T., C.Z., R.N.W., L.M.Z., F.A.M.). Publisher Copyright: {\textcopyright} 2015 Elsevier Inc. ALL RIGHTS RESERVED.",
year = "2015",
month = jan,
day = "1",
doi = "10.1016/j.ajo.2014.10.019",
language = "English (US)",
volume = "159",
pages = "193--201",
journal = "American journal of ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "1",
}