Diagnosis of Alzheimer's disease: Two decades of progress

Zaven S. Khachaturian

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


A retrospective view of the critical events and advances in the development of criteria, instruments and algorithms in the diagnosis of Alzheimer's disease. The review is from the vantage point of the National Institute on Aging and its role in the development of the national infrastructure, in the US, for clinical research on dementia. The paper discusses future research needs and challenges for developing new diagnostic armamentarium for early and accurate detection of neurodegenerative processes of dementia in the early prodromal stages or during early mild cognitive impairments.

Original languageEnglish (US)
Pages (from-to)93-98
Number of pages6
JournalAlzheimer's and Dementia
Issue number2
StatePublished - Oct 2005
Externally publishedYes


  • Alzheimer's disease
  • Biomarkers
  • Dementia
  • Diagnosis
  • Diagnostic criteria
  • Diagnostic instruments
  • MCI
  • Mild cognitive impairment
  • National Institute on Aging
  • Neuroimaging
  • NIA
  • NIH

ASJC Scopus subject areas

  • Health Policy
  • Epidemiology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology


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