Diagnosis and staging of ovarian cancer: Comparative values of doppler and conventional US, CT, and MR imaging correlated with surgery and histopathologic analysis - Report of the radiology diagnostic oncology group

Alfred B. Kurtz; John V. Tsimikas; Clare M.C. Tempany; Ulrike M. Hamper; Peter H. Arger; Robert L. Bree; Richard J. Wechler; Isaac R. Francis; Janet E. Kuhlman; Evan S. Siegelman; Donald G. Mitchell; Stuart G. Silverman; Douglas L. Brown; Sheila Sheth; Beverly G. Coleman; James H. Ellis; Robert J. Kurman; Daryl J. Caudry; Barbara J. McNell

doi:10.1148/radiology.212.1.r99jl3619

Diagnosis and staging of ovarian cancer: Comparative values of doppler and conventional US, CT, and MR imaging correlated with surgery and histopathologic analysis - Report of the radiology diagnostic oncology group

Alfred B. Kurtz, John V. Tsimikas, Clare M.C. Tempany, Ulrike M. Hamper, Peter H. Arger, Robert L. Bree, Richard J. Wechler, Isaac R. Francis, Janet E. Kuhlman, Evan S. Siegelman, Donald G. Mitchell, Stuart G. Silverman, Douglas L. Brown, Sheila Sheth, Beverly G. Coleman, James H. Ellis, Robert J. Kurman, Daryl J. Caudry, Barbara J. McNell

School of Medicine

Research output: Contribution to journal › Article › peer-review

203 Scopus citations

Abstract

PURPOSE: To determine the optimal imaging modality for diagnosis and staging of ovarian cancer. Material and Methods: Two hundred eighty women suspected to have ovarian cancer were enrolled in a prospective study before surgery. Doppler ultrasonography (US), computed tomography (CT), and magnetic resonance (MR) imaging were used to evaluate the mass; conventional US, CT, and MR imaging were used to stage spread. RESULTS: All three modalities had high accuracy (0.91) for the overall diagnosis of malignancy. In the ovaries, the accuracy of MR imaging (0.91) was higher than that of CT and significantly higher than that of Doppler US (0.78). In the extraovarian pelvis and in the abdomen, conventional US, CT, and MR imaging had similar accuracies (0.87-0.95). In differentiation of disease confined to the pelvis from abdominal spread, the specificity of conventional US (96%) was higher than that of CT and significantly higher than that of MR imaging (88%), whereas the sensitivities of MR imaging (98%) and CT (92%) were significantly higher than that of conventional US (75%). CONCLUSION: MR imaging is superior to Doppler US and CT in diagnosis of malignant ovarian masses. There is little variation among conventional US, CT, and MR imaging as regards staging.

Original language	English (US)
Pages (from-to)	19-27
Number of pages	9
Journal	RADIOLOGY
Volume	212
Issue number	1
DOIs	https://doi.org/10.1148/radiology.212.1.r99jl3619
State	Published - Jul 1999

Keywords

Computed tomography (CT), comparative studies
Magnetic resonance (MR), comparative studies
Ovary, neoplasms
Receiver operating characteristic curve (ROC)
Ultrasound (US), Doppler studies
Ultrasound (US), comparative studies

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1148/radiology.212.1.r99jl3619

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Kurtz, A. B., Tsimikas, J. V., Tempany, C. M. C., Hamper, U. M., Arger, P. H., Bree, R. L., Wechler, R. J., Francis, I. R., Kuhlman, J. E., Siegelman, E. S., Mitchell, D. G., Silverman, S. G., Brown, D. L., Sheth, S., Coleman, B. G., Ellis, J. H., Kurman, R. J., Caudry, D. J., & McNell, B. J. (1999). Diagnosis and staging of ovarian cancer: Comparative values of doppler and conventional US, CT, and MR imaging correlated with surgery and histopathologic analysis - Report of the radiology diagnostic oncology group. RADIOLOGY, 212(1), 19-27. https://doi.org/10.1148/radiology.212.1.r99jl3619

Diagnosis and staging of ovarian cancer: Comparative values of doppler and conventional US, CT, and MR imaging correlated with surgery and histopathologic analysis - Report of the radiology diagnostic oncology group. / Kurtz, Alfred B.; Tsimikas, John V.; Tempany, Clare M.C. et al.
In: RADIOLOGY, Vol. 212, No. 1, 07.1999, p. 19-27.

Research output: Contribution to journal › Article › peer-review

Kurtz, AB, Tsimikas, JV, Tempany, CMC, Hamper, UM, Arger, PH, Bree, RL, Wechler, RJ, Francis, IR, Kuhlman, JE, Siegelman, ES, Mitchell, DG, Silverman, SG, Brown, DL, Sheth, S, Coleman, BG, Ellis, JH, Kurman, RJ, Caudry, DJ & McNell, BJ 1999, 'Diagnosis and staging of ovarian cancer: Comparative values of doppler and conventional US, CT, and MR imaging correlated with surgery and histopathologic analysis - Report of the radiology diagnostic oncology group', RADIOLOGY, vol. 212, no. 1, pp. 19-27. https://doi.org/10.1148/radiology.212.1.r99jl3619

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title = "Diagnosis and staging of ovarian cancer: Comparative values of doppler and conventional US, CT, and MR imaging correlated with surgery and histopathologic analysis - Report of the radiology diagnostic oncology group",

abstract = "PURPOSE: To determine the optimal imaging modality for diagnosis and staging of ovarian cancer. Material and Methods: Two hundred eighty women suspected to have ovarian cancer were enrolled in a prospective study before surgery. Doppler ultrasonography (US), computed tomography (CT), and magnetic resonance (MR) imaging were used to evaluate the mass; conventional US, CT, and MR imaging were used to stage spread. RESULTS: All three modalities had high accuracy (0.91) for the overall diagnosis of malignancy. In the ovaries, the accuracy of MR imaging (0.91) was higher than that of CT and significantly higher than that of Doppler US (0.78). In the extraovarian pelvis and in the abdomen, conventional US, CT, and MR imaging had similar accuracies (0.87-0.95). In differentiation of disease confined to the pelvis from abdominal spread, the specificity of conventional US (96%) was higher than that of CT and significantly higher than that of MR imaging (88%), whereas the sensitivities of MR imaging (98%) and CT (92%) were significantly higher than that of conventional US (75%). CONCLUSION: MR imaging is superior to Doppler US and CT in diagnosis of malignant ovarian masses. There is little variation among conventional US, CT, and MR imaging as regards staging.",

keywords = "Computed tomography (CT), comparative studies, Magnetic resonance (MR), comparative studies, Ovary, neoplasms, Receiver operating characteristic curve (ROC), Ultrasound (US), Doppler studies, Ultrasound (US), comparative studies",

author = "Kurtz, {Alfred B.} and Tsimikas, {John V.} and Tempany, {Clare M.C.} and Hamper, {Ulrike M.} and Arger, {Peter H.} and Bree, {Robert L.} and Wechler, {Richard J.} and Francis, {Isaac R.} and Kuhlman, {Janet E.} and Siegelman, {Evan S.} and Mitchell, {Donald G.} and Silverman, {Stuart G.} and Brown, {Douglas L.} and Sheila Sheth and Coleman, {Beverly G.} and Ellis, {James H.} and Kurman, {Robert J.} and Caudry, {Daryl J.} and McNell, {Barbara J.}",

year = "1999",

month = jul,

doi = "10.1148/radiology.212.1.r99jl3619",

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TY - JOUR

T1 - Diagnosis and staging of ovarian cancer

T2 - Comparative values of doppler and conventional US, CT, and MR imaging correlated with surgery and histopathologic analysis - Report of the radiology diagnostic oncology group

AU - Kurtz, Alfred B.

AU - Tsimikas, John V.

AU - Tempany, Clare M.C.

AU - Hamper, Ulrike M.

AU - Arger, Peter H.

AU - Bree, Robert L.

AU - Wechler, Richard J.

AU - Francis, Isaac R.

AU - Kuhlman, Janet E.

AU - Siegelman, Evan S.

AU - Mitchell, Donald G.

AU - Silverman, Stuart G.

AU - Brown, Douglas L.

AU - Sheth, Sheila

AU - Coleman, Beverly G.

AU - Ellis, James H.

AU - Kurman, Robert J.

AU - Caudry, Daryl J.

AU - McNell, Barbara J.

PY - 1999/7

Y1 - 1999/7

N2 - PURPOSE: To determine the optimal imaging modality for diagnosis and staging of ovarian cancer. Material and Methods: Two hundred eighty women suspected to have ovarian cancer were enrolled in a prospective study before surgery. Doppler ultrasonography (US), computed tomography (CT), and magnetic resonance (MR) imaging were used to evaluate the mass; conventional US, CT, and MR imaging were used to stage spread. RESULTS: All three modalities had high accuracy (0.91) for the overall diagnosis of malignancy. In the ovaries, the accuracy of MR imaging (0.91) was higher than that of CT and significantly higher than that of Doppler US (0.78). In the extraovarian pelvis and in the abdomen, conventional US, CT, and MR imaging had similar accuracies (0.87-0.95). In differentiation of disease confined to the pelvis from abdominal spread, the specificity of conventional US (96%) was higher than that of CT and significantly higher than that of MR imaging (88%), whereas the sensitivities of MR imaging (98%) and CT (92%) were significantly higher than that of conventional US (75%). CONCLUSION: MR imaging is superior to Doppler US and CT in diagnosis of malignant ovarian masses. There is little variation among conventional US, CT, and MR imaging as regards staging.

AB - PURPOSE: To determine the optimal imaging modality for diagnosis and staging of ovarian cancer. Material and Methods: Two hundred eighty women suspected to have ovarian cancer were enrolled in a prospective study before surgery. Doppler ultrasonography (US), computed tomography (CT), and magnetic resonance (MR) imaging were used to evaluate the mass; conventional US, CT, and MR imaging were used to stage spread. RESULTS: All three modalities had high accuracy (0.91) for the overall diagnosis of malignancy. In the ovaries, the accuracy of MR imaging (0.91) was higher than that of CT and significantly higher than that of Doppler US (0.78). In the extraovarian pelvis and in the abdomen, conventional US, CT, and MR imaging had similar accuracies (0.87-0.95). In differentiation of disease confined to the pelvis from abdominal spread, the specificity of conventional US (96%) was higher than that of CT and significantly higher than that of MR imaging (88%), whereas the sensitivities of MR imaging (98%) and CT (92%) were significantly higher than that of conventional US (75%). CONCLUSION: MR imaging is superior to Doppler US and CT in diagnosis of malignant ovarian masses. There is little variation among conventional US, CT, and MR imaging as regards staging.

KW - Computed tomography (CT), comparative studies

KW - Magnetic resonance (MR), comparative studies

KW - Ovary, neoplasms

KW - Receiver operating characteristic curve (ROC)

KW - Ultrasound (US), Doppler studies

KW - Ultrasound (US), comparative studies

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SN - 0033-8419

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Diagnosis and staging of ovarian cancer: Comparative values of doppler and conventional US, CT, and MR imaging correlated with surgery and histopathologic analysis - Report of the radiology diagnostic oncology group

Abstract

Keywords

ASJC Scopus subject areas

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