Diagnosis and management of secondary-progressive multiple sclerosis: Time for change

Jiwon Oh, Katayoun Alikhani, Tania Bruno, Virginia Devonshire, Paul S. Giacomini, Fabrizio Giuliani, Hamid R. Nakhaipour, Robyn Schecter, Catherine Larochelle

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Identifying the transition of relapsing-remitting multiple sclerosis (MS) to the secondary-progressive MS form remains a clinical challenge due to the gradual nature of the transition, superimposed relapses, the heterogeneous course of disease among patients and the absence of validated biomarkers and diagnostic tools. The uncertainty associated with the transition makes clinical care challenging for both patients and physicians. The emergence of new disease-modifying treatments for progressive MS and the increasing emphasis of nonpharmacological strategies mark a new era in the treatment of progressive MS. This article summarizes challenges in diagnosis and management, discusses novel treatment strategies and highlights the importance of establishing a clear diagnosis and instituting an interdisciplinary management plan in the care of patients with progressive MS.

Original languageEnglish (US)
Pages (from-to)301-317
Number of pages17
JournalNeurodegenerative disease management
Issue number6
StatePublished - Dec 2019
Externally publishedYes


  • biomarkers
  • disease-modifying therapy
  • inflammation
  • neuroprotective
  • secondary-progressive multiple sclerosis

ASJC Scopus subject areas

  • Medicine(all)


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