Diagnosis and management of latent tuberculosis infection in Asia: Review of current status and challenges

Nicholas I. Paton, Laurence Borand, Jubert Benedicto, Mar Mar Kyi, Asif Mujtaba Mahmud, Mohd Nor Norazmi, Nandini Sharma, Charoen Chuchottaworn, Yi Wen Huang, Nastiti Kaswandani, Hoi Le Van, Grace C.Y. Lui, Tan Eang Mao

Research output: Contribution to journalReview articlepeer-review


Asia has the highest burden of tuberculosis (TB) and latent TB infection (LTBI) in the world. Optimizing the diagnosis and treatment of LTBI is one of the key strategies for achieving the WHO ‘End TB’ targets. We report the discussions from the Asia Latent TubERculosis (ALTER) expert panel meeting held in 2018 in Singapore. In this meeting, a group of 13 TB experts from Bangladesh, Cambodia, Hong Kong, India, Indonesia, Malaysia, Myanmar, the Philippines, Singapore, Taiwan, Thailand and Vietnam convened to review the literature, discuss the barriers and propose strategies to improve the management of LTBI in Asia. Strategies for the optimization of risk group prioritization, diagnosis, treatment, and research of LTBI are reported. The perspectives presented herein, may help national programs and professional societies of the respective countries enhance the adoption of the WHO guidelines, scale-up the implementation of national guidelines based on the regional needs, and provide optimal guidance to clinicians for the programmatic management of LTBI.

Original languageEnglish (US)
Pages (from-to)21-29
Number of pages9
JournalInternational Journal of Infectious Diseases
StatePublished - Oct 2019
Externally publishedYes


  • Asia
  • Awareness
  • Latent tuberculosis infection
  • Optimization

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


Dive into the research topics of 'Diagnosis and management of latent tuberculosis infection in Asia: Review of current status and challenges'. Together they form a unique fingerprint.

Cite this