Abstract
Diabetic retinopathy remains a major threat to sight in the working-age population in the developed world. In proliferative diabetic retinopathy (PDR), the growth of new vessels is thought to occur as a result of vascular endothelial growth factor (VEGF) release into the vitreous cavity as a response to ischemia, which facilitates the process of angiogenesis and macular edema. In these patients, the introduction of new therapies, such as VEGF inhibitors, may have a beneficial effect on diabetic retinopathy including diabetic macular edema and retinal neovascularization, and these therapies could complement laser photocoagulation treatment.
Original language | English (US) |
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Title of host publication | Retinal and Choroidal Manifestations of Selected Systemic Diseases |
Publisher | Springer New York |
Pages | 387-416 |
Number of pages | 30 |
ISBN (Electronic) | 9781461436461 |
ISBN (Print) | 9781461436454 |
DOIs | |
State | Published - Jan 1 2013 |
Keywords
- Diffuse diabetic macular edema
- Nonproliferative diabetic retinopathy
- Proliferative diabetic retinopathy
- Retinal photocoagulation
- Tractional retinal detachment
- VEGF inhibitors
- Vascular endothelial growth factor
ASJC Scopus subject areas
- Medicine(all)