TY - JOUR
T1 - Diabetes, Intraocular Pressure, and Primary Open-angle Glaucoma in the Baltimore Eye Survey
AU - Tielsch, James M.
AU - Katz, Joanne
AU - Quigley, Harry A.
AU - Javitt, Jonathan C.
AU - Sommer, Alfred
N1 - Funding Information:
Originally received: March 7, 1994. Revision accepted: July 12, 1994. I Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University Schools of Medicine and Public Health, Baltimore. 2 Worthen Center, Department of Ophthalmology, Georgetown University School of Medicine, Washington, DC. 3 Office of the Dean, The Johns Hopkins University School of Hygiene and Public Health, Baltimore. Supported in part by grants EY05091, EY09672, and RR04060 from the National Institutes of Health, Bethesda, Maryland. Reprint requests to James M. Tielsch, PhD, Dana Center for Preventive Ophthalmology, Wilmer 120,600 N. Wolfe St, Baltimore, MD 21205.
PY - 1995
Y1 - 1995
N2 - Background: The association of diabetes with primary-open angle glaucoma (POAG) has been controversial and often confused by varying definitions of both diabetes and POAG. The purpose of this study is to evaluate this association in a populationbased sample of subjects from the Baltimore Eye Survey. Methods: A stratified sample of residents in 16 cluster areas of east Baltimore was recruited for a detailed ophthalmologic screening examination. A total of 5308 black subjects and white subjects participated. Of these participants,161 received a diagnosis of POAG. During a detailed interview with each subject, diabetes was defined based on a reported history of diabetes. Persons with diabetes were classified as “insulinusers” and “noninsulin-users” based on their current method of treatment. Results: Diabetes was highly prevalent in this population, with 10.6% of white subjects and 17.2% of black subjects reporting a positive history. Diabetes was associated with higher intraocular pressure, but differences were not large (means,17.4,18.0, and 17.8 mmHg) among subjects without diabetes, those with diabetes who were not using insulin, and those with diabetes who were using insulin, respectively. Diabetes was not associated with POAG (age-race-adjusted odds ratio, 1.03; 95% confidence interval, 0.85, 1.25. This was true for both types of diabetes. Persons whose POAG had been diagnosed before the examination showed a positive association with diabetes (odds ratio, l .7, 95% confidence interva1,1.03, 2.86), indicating that selection bias could explain the positive results of previous clinic-based investigations. Conclusion: There is no evidence from this population-based investigation that supports an association between diabetes and POAG.
AB - Background: The association of diabetes with primary-open angle glaucoma (POAG) has been controversial and often confused by varying definitions of both diabetes and POAG. The purpose of this study is to evaluate this association in a populationbased sample of subjects from the Baltimore Eye Survey. Methods: A stratified sample of residents in 16 cluster areas of east Baltimore was recruited for a detailed ophthalmologic screening examination. A total of 5308 black subjects and white subjects participated. Of these participants,161 received a diagnosis of POAG. During a detailed interview with each subject, diabetes was defined based on a reported history of diabetes. Persons with diabetes were classified as “insulinusers” and “noninsulin-users” based on their current method of treatment. Results: Diabetes was highly prevalent in this population, with 10.6% of white subjects and 17.2% of black subjects reporting a positive history. Diabetes was associated with higher intraocular pressure, but differences were not large (means,17.4,18.0, and 17.8 mmHg) among subjects without diabetes, those with diabetes who were not using insulin, and those with diabetes who were using insulin, respectively. Diabetes was not associated with POAG (age-race-adjusted odds ratio, 1.03; 95% confidence interval, 0.85, 1.25. This was true for both types of diabetes. Persons whose POAG had been diagnosed before the examination showed a positive association with diabetes (odds ratio, l .7, 95% confidence interva1,1.03, 2.86), indicating that selection bias could explain the positive results of previous clinic-based investigations. Conclusion: There is no evidence from this population-based investigation that supports an association between diabetes and POAG.
UR - http://www.scopus.com/inward/record.url?scp=0028819158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028819158&partnerID=8YFLogxK
U2 - 10.1016/S0161-6420(95)31055-X
DO - 10.1016/S0161-6420(95)31055-X
M3 - Article
C2 - 7831041
AN - SCOPUS:0028819158
SN - 0161-6420
VL - 102
SP - 48
EP - 53
JO - Ophthalmology
JF - Ophthalmology
IS - 1
ER -