Diabetes and O-Glcnacylation

Yoshihiro Akimoto; Yuri Miura; Tamao Endo; Hayato Kawakami; Gerald Warren Hart

doi:10.1007/978-4-431-54841-6_84

Diabetes and O-Glcnacylation

Yoshihiro Akimoto, Yuri Miura, Tamao Endo, Hayato Kawakami, Gerald Warren Hart

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

O-Linked β-N-acetylglucosamine modification (O-GlcNAcylation) of proteins is a dynamic posttranslational modification which occurs in the nucleus and the cytoplasm. Increase of O-GlcNAcylation is involved in the glucose toxicity and chronic hyperglycemia-induced insulin resistance, a major hallmark of type 2 diabetes. O-GlcNAcylation is regulated by the concerted actions of O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Studies on the overexpression of OGT and knockdown of OGA demonstrate that elevation of O-GlcNAcylation through the hexosamine biosynthetic pathway plays an important role in the development of glucose resistance and diabetic complications. This chapter overviews the role of O-GlcNAc in the type 2 diabetes and diabetic complications and the methods of analysis of O-GlcNAcylation in diabetes.

Original language	English (US)
Title of host publication	Glycoscience: Biology and Medicine
Publisher	Springer Japan
Pages	1207-1212
Number of pages	6
ISBN (Print)	9784431548416, 9784431548409
DOIs	https://doi.org/10.1007/978-4-431-54841-6_84
State	Published - Jan 1 2015

Keywords

Diabetes
Insulin resistance
O-GlcNAc transferase
O-GlcNAcase
O-GlcNAcylation

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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10.1007/978-4-431-54841-6_84

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title = "Diabetes and O-Glcnacylation",

abstract = "O-Linked β-N-acetylglucosamine modification (O-GlcNAcylation) of proteins is a dynamic posttranslational modification which occurs in the nucleus and the cytoplasm. Increase of O-GlcNAcylation is involved in the glucose toxicity and chronic hyperglycemia-induced insulin resistance, a major hallmark of type 2 diabetes. O-GlcNAcylation is regulated by the concerted actions of O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Studies on the overexpression of OGT and knockdown of OGA demonstrate that elevation of O-GlcNAcylation through the hexosamine biosynthetic pathway plays an important role in the development of glucose resistance and diabetic complications. This chapter overviews the role of O-GlcNAc in the type 2 diabetes and diabetic complications and the methods of analysis of O-GlcNAcylation in diabetes.",

keywords = "Diabetes, Insulin resistance, O-GlcNAc transferase, O-GlcNAcase, O-GlcNAcylation",

author = "Yoshihiro Akimoto and Yuri Miura and Tamao Endo and Hayato Kawakami and Hart, {Gerald Warren}",

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doi = "10.1007/978-4-431-54841-6_84",

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T1 - Diabetes and O-Glcnacylation

AU - Akimoto, Yoshihiro

AU - Miura, Yuri

AU - Endo, Tamao

AU - Kawakami, Hayato

AU - Hart, Gerald Warren

PY - 2015/1/1

Y1 - 2015/1/1

N2 - O-Linked β-N-acetylglucosamine modification (O-GlcNAcylation) of proteins is a dynamic posttranslational modification which occurs in the nucleus and the cytoplasm. Increase of O-GlcNAcylation is involved in the glucose toxicity and chronic hyperglycemia-induced insulin resistance, a major hallmark of type 2 diabetes. O-GlcNAcylation is regulated by the concerted actions of O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Studies on the overexpression of OGT and knockdown of OGA demonstrate that elevation of O-GlcNAcylation through the hexosamine biosynthetic pathway plays an important role in the development of glucose resistance and diabetic complications. This chapter overviews the role of O-GlcNAc in the type 2 diabetes and diabetic complications and the methods of analysis of O-GlcNAcylation in diabetes.

AB - O-Linked β-N-acetylglucosamine modification (O-GlcNAcylation) of proteins is a dynamic posttranslational modification which occurs in the nucleus and the cytoplasm. Increase of O-GlcNAcylation is involved in the glucose toxicity and chronic hyperglycemia-induced insulin resistance, a major hallmark of type 2 diabetes. O-GlcNAcylation is regulated by the concerted actions of O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Studies on the overexpression of OGT and knockdown of OGA demonstrate that elevation of O-GlcNAcylation through the hexosamine biosynthetic pathway plays an important role in the development of glucose resistance and diabetic complications. This chapter overviews the role of O-GlcNAc in the type 2 diabetes and diabetic complications and the methods of analysis of O-GlcNAcylation in diabetes.

KW - Diabetes

KW - Insulin resistance

KW - O-GlcNAc transferase

KW - O-GlcNAcase

KW - O-GlcNAcylation

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SN - 9784431548416

SN - 9784431548409

SP - 1207

EP - 1212

BT - Glycoscience: Biology and Medicine

PB - Springer Japan

ER -

Diabetes and O-Glcnacylation

Abstract

Keywords

ASJC Scopus subject areas

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