Diabetes and LOH syndrome

Age-related declines in androgen levels lead to impaired organ function known as late-onset hypogonadism (LOH). Various diseases are considered to be involved in the emergence of LOH, among which are diabetes, metabolic syndrome, arteriosclerosis, hypertension, and hyperlipidemia. Testosterone increases insulin sensitivity in muscle through functional mitochondria in muscle tissue, while lowered testosterone conversely leads to reduced glucose uptake in muscle. Diabetes mellitus (DM) and LOH are deeply interrelated diseases requiring further clinical research results in areas including diagnosis and treatment.