TY - JOUR
T1 - Dextromethorphan From Cough Suppressant to Antidepressant
AU - Kverno, Karan
N1 - Publisher Copyright:
© 2022, Slack Incorporated. All rights reserved.
PY - 2022/11
Y1 - 2022/11
N2 - Dextromethorphan (DXM) has been re-purposed several times over the past 7 decades: first as a cough suppressant, then as a compounded formulation with quinidine for treatment of pseu-dobulbar affect, and most recently as a compounded formulation with bupro-pion for treatment of major depressive disorder. The current article describes the history and purported mechanisms of action of DXM for each use and the uniquely rapid action and safety pro-file of the oral dextromethorphan– bupropion antidepressant formulation.
AB - Dextromethorphan (DXM) has been re-purposed several times over the past 7 decades: first as a cough suppressant, then as a compounded formulation with quinidine for treatment of pseu-dobulbar affect, and most recently as a compounded formulation with bupro-pion for treatment of major depressive disorder. The current article describes the history and purported mechanisms of action of DXM for each use and the uniquely rapid action and safety pro-file of the oral dextromethorphan– bupropion antidepressant formulation.
UR - http://www.scopus.com/inward/record.url?scp=85140934281&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85140934281&partnerID=8YFLogxK
U2 - 10.3928/02793695-20221005-02
DO - 10.3928/02793695-20221005-02
M3 - Article
C2 - 36317836
AN - SCOPUS:85140934281
SN - 0279-3695
VL - 60
SP - 9
EP - 11
JO - Journal of psychosocial nursing and mental health services
JF - Journal of psychosocial nursing and mental health services
IS - 11
ER -