Dextromethorphan From Cough Suppressant to Antidepressant

Karan Kverno

Research output: Contribution to journalArticlepeer-review


Dextromethorphan (DXM) has been re-purposed several times over the past 7 decades: first as a cough suppressant, then as a compounded formulation with quinidine for treatment of pseu-dobulbar affect, and most recently as a compounded formulation with bupro-pion for treatment of major depressive disorder. The current article describes the history and purported mechanisms of action of DXM for each use and the uniquely rapid action and safety pro-file of the oral dextromethorphan– bupropion antidepressant formulation.

Original languageEnglish (US)
Pages (from-to)9-11
Number of pages3
JournalJournal of psychosocial nursing and mental health services
Issue number11
StatePublished - Nov 2022

ASJC Scopus subject areas

  • General Nursing
  • Phychiatric Mental Health


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