Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity

Jiyoung Y. Cha; Hyo Jung Kim; Jung Hwan Yu; Jing Xu; Daham Kim; Bindu D. Paul; Hyeonjin Choi; Seyun Kim; Yoo Jeong Lee; Gary P. Ho; Feng Rao; Solomon H. Snyder; Jae Woo Kim

doi:10.1073/pnas.1320454110

Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity

Jiyoung Y. Cha, Hyo Jung Kim, Jung Hwan Yu, Jing Xu, Daham Kim, Bindu D. Paul, Hyeonjin Choi, Seyun Kim, Yoo Jeong Lee, Gary P. Ho, Feng Rao, Solomon H. Snyder, Jae Woo Kim

School of Medicine

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Adipogenesis, the conversion of precursor cells into adipocytes, is associated with obesity and is mediated by glucocorticoids acting via hitherto poorly characterized mechanisms. Dexras1 is a small G protein of the Ras family discovered on the basis of its marked induction by the synthetic glucocorticoid dexamethasone. We show that Dexras1 mediates adipogenesis and diet-induced obesity. Adipogenic differentiation of 3T3-L1 cells is abolished with Dexras1 depletion, whereas overexpression of Dexras1 elicits adipogenesis. Adipogenesis is markedly reduced in mouse embryonic fibroblasts from Dexras1-deleted mice, whereas adiposity and dietinduced weight gain are diminished in the mutant mice.

Original language	English (US)
Pages (from-to)	20575-20580
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	110
Issue number	51
DOIs	https://doi.org/10.1073/pnas.1320454110
State	Published - Dec 17 2013

Keywords

Cushing disease
Cyclic AMP
Insulin
Nitric oxide

ASJC Scopus subject areas

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Cha, J. Y., Kim, H. J., Yu, J. H., Xu, J., Kim, D., Paul, B. D., Choi, H., Kim, S., Lee, Y. J., Ho, G. P., Rao, F., Snyder, S. H., & Kim, J. W. (2013). Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity. Proceedings of the National Academy of Sciences of the United States of America, 110(51), 20575-20580. https://doi.org/10.1073/pnas.1320454110

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title = "Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity",

abstract = "Adipogenesis, the conversion of precursor cells into adipocytes, is associated with obesity and is mediated by glucocorticoids acting via hitherto poorly characterized mechanisms. Dexras1 is a small G protein of the Ras family discovered on the basis of its marked induction by the synthetic glucocorticoid dexamethasone. We show that Dexras1 mediates adipogenesis and diet-induced obesity. Adipogenic differentiation of 3T3-L1 cells is abolished with Dexras1 depletion, whereas overexpression of Dexras1 elicits adipogenesis. Adipogenesis is markedly reduced in mouse embryonic fibroblasts from Dexras1-deleted mice, whereas adiposity and dietinduced weight gain are diminished in the mutant mice.",

keywords = "Cushing disease, Cyclic AMP, Insulin, Nitric oxide",

author = "Cha, {Jiyoung Y.} and Kim, {Hyo Jung} and Yu, {Jung Hwan} and Jing Xu and Daham Kim and Paul, {Bindu D.} and Hyeonjin Choi and Seyun Kim and Lee, {Yoo Jeong} and Ho, {Gary P.} and Feng Rao and Snyder, {Solomon H.} and Kim, {Jae Woo}",

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doi = "10.1073/pnas.1320454110",

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AU - Cha, Jiyoung Y.

AU - Kim, Hyo Jung

AU - Yu, Jung Hwan

AU - Xu, Jing

AU - Kim, Daham

AU - Paul, Bindu D.

AU - Choi, Hyeonjin

AU - Kim, Seyun

AU - Lee, Yoo Jeong

AU - Ho, Gary P.

AU - Rao, Feng

AU - Snyder, Solomon H.

AU - Kim, Jae Woo

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AB - Adipogenesis, the conversion of precursor cells into adipocytes, is associated with obesity and is mediated by glucocorticoids acting via hitherto poorly characterized mechanisms. Dexras1 is a small G protein of the Ras family discovered on the basis of its marked induction by the synthetic glucocorticoid dexamethasone. We show that Dexras1 mediates adipogenesis and diet-induced obesity. Adipogenic differentiation of 3T3-L1 cells is abolished with Dexras1 depletion, whereas overexpression of Dexras1 elicits adipogenesis. Adipogenesis is markedly reduced in mouse embryonic fibroblasts from Dexras1-deleted mice, whereas adiposity and dietinduced weight gain are diminished in the mutant mice.

KW - Cushing disease

KW - Cyclic AMP

KW - Insulin

KW - Nitric oxide

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JF - Proceedings of the National Academy of Sciences of the United States of America

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ER -

Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity

Abstract

Keywords

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