Dexamethasone Protection Against Photochemical Retinal Injury

Leonard M. Parver; Charles R. Auker; Ben S. Fine; Thomas Doyle

doi:10.1001/archopht.1984.01040030620035

Dexamethasone Protection Against Photochemical Retinal Injury

Leonard M. Parver, Charles R. Auker, Ben S. Fine, Thomas Doyle

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8 Scopus citations

Abstract

Photochemical retinal injury was produced in the foveomacula of the rhesus monkey using the light from an indirect ophthalmoscope. The eyes were examined by both light and electron microscopy. Damage consisted of vacuolization of the retinal pigment epithelium and neurosensory retinal layers. Pretreatment with subcutaneous injection of dexamethasone for 16 weeks prior to light exposure markedly decreased damage to the retinal pigment epithelium, but had no apparent effect on damage to the neurosensory retina in eyes examined 18 hours after exposure. The mechanism responsible for this protective effect is unknown.

Original language	English (US)
Pages (from-to)	772-777
Number of pages	6
Journal	Archives of ophthalmology
Volume	102
Issue number	5
DOIs	https://doi.org/10.1001/archopht.1984.01040030620035
State	Published - May 1984
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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10.1001/archopht.1984.01040030620035

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author = "Parver, {Leonard M.} and Auker, {Charles R.} and Fine, {Ben S.} and Thomas Doyle",

year = "1984",

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AU - Fine, Ben S.

AU - Doyle, Thomas

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AB - Photochemical retinal injury was produced in the foveomacula of the rhesus monkey using the light from an indirect ophthalmoscope. The eyes were examined by both light and electron microscopy. Damage consisted of vacuolization of the retinal pigment epithelium and neurosensory retinal layers. Pretreatment with subcutaneous injection of dexamethasone for 16 weeks prior to light exposure markedly decreased damage to the retinal pigment epithelium, but had no apparent effect on damage to the neurosensory retina in eyes examined 18 hours after exposure. The mechanism responsible for this protective effect is unknown.

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Dexamethasone Protection Against Photochemical Retinal Injury

Abstract

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