Developmental regression and autism reported to the Vaccine Adverse Event Reporting System

Emily Jane Woo; Robert Ball; Rebecca Landa; Andrew W. Zimmerman; M. Miles Braun; Marthe Bryant-Genevier; Dale R. Burwen; Soju Chang; Azra Dobardzic; Hector Izurieta; Ann W. McMahon; Phil Perucci; Lise Stevens; Scott Campbell; Penina Haber; John Iskander; Elaine Miller; Gina T. Mootrey; Vito Caserta

doi:10.1177/1362361307078126

Developmental regression and autism reported to the Vaccine Adverse Event Reporting System

Emily Jane Woo, Robert Ball, Rebecca Landa, Andrew W. Zimmerman, M. Miles Braun, Marthe Bryant-Genevier, Dale R. Burwen, Soju Chang, Azra Dobardzic, Hector Izurieta, Ann W. McMahon, Phil Perucci, Lise Stevens, Scott Campbell, Penina Haber, John Iskander, Elaine Miller, Gina T. Mootrey, Vito Caserta

Kennedy Krieger Institute

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We report demographic and clinical characteristics of children reported to the US Vaccine Adverse Event Reporting System (VAERS) as having autism or another developmental disorder after vaccination. We completed 124 interviews with parents and reviewed medical records for 31 children whose records contained sufficient information to evaluate the child's developmental history. Medical record review indicated that 27 of 31 (87%) children had autism/ASD and 19 (61.3%) had evidence of developmental regression (loss of social, language, or motor skills). The proportion of VAERS cases of autism with regression was greater than that reported in population-based studies, based on the subset of VAERS cases with medical record confirmation. This difference may reflect preferential reporting to VAERS of autism with regression. In other respects, the children in this study appear to be similar to other children with autism. Further research might determine whether the pathogenesis of autism with developmental regression differs from that of autism without regression.

Original language	English (US)
Pages (from-to)	301-310
Number of pages	10
Journal	Autism
Volume	11
Issue number	4
DOIs	https://doi.org/10.1177/1362361307078126
State	Published - Jul 2007

Keywords

Adverse event
Autism
Regression
Vaccine

ASJC Scopus subject areas

Developmental and Educational Psychology

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10.1177/1362361307078126

Cite this

Woo, E. J., Ball, R., Landa, R., Zimmerman, A. W., Braun, M. M., Bryant-Genevier, M., Burwen, D. R., Chang, S., Dobardzic, A., Izurieta, H., McMahon, A. W., Perucci, P., Stevens, L., Campbell, S., Haber, P., Iskander, J., Miller, E., Mootrey, G. T., & Caserta, V. (2007). Developmental regression and autism reported to the Vaccine Adverse Event Reporting System. Autism, 11(4), 301-310. https://doi.org/10.1177/1362361307078126

Woo, EJ, Ball, R, Landa, R, Zimmerman, AW, Braun, MM, Bryant-Genevier, M, Burwen, DR, Chang, S, Dobardzic, A, Izurieta, H, McMahon, AW, Perucci, P, Stevens, L, Campbell, S, Haber, P, Iskander, J, Miller, E, Mootrey, GT & Caserta, V 2007, 'Developmental regression and autism reported to the Vaccine Adverse Event Reporting System', Autism, vol. 11, no. 4, pp. 301-310. https://doi.org/10.1177/1362361307078126

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AU - Dobardzic, Azra

AU - Izurieta, Hector

AU - McMahon, Ann W.

AU - Perucci, Phil

AU - Stevens, Lise

AU - Campbell, Scott

AU - Haber, Penina

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AU - Mootrey, Gina T.

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Developmental regression and autism reported to the Vaccine Adverse Event Reporting System

Abstract

Keywords

ASJC Scopus subject areas

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