Developmental Neurotoxicology From Regulatory Testing Perspective: History, Achievements and Challenges

Yifei Wang; Antonia Egert; Maren Schenke; Lena Smirnova; Breanne Kincaid

doi:10.1016/B978-0-323-95488-4.00187-X

Developmental Neurotoxicology From Regulatory Testing Perspective: History, Achievements and Challenges

Yifei Wang
, Antonia Egert
, Maren Schenke
, Lena Smirnova
, Breanne Kincaid

Bloomberg School of Public Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

With increasing concern over the risks of environmental exposure in daily life, the need for more rigorous developmental neurotoxicity testing methodologies and routine risk assessment strategies has grown notably. This chapter provides a comprehensive overview of developmental neurotoxicity (DNT) from the regulator testing perspective. In addition to a thorough background on DNT, this chapter highlights the application of human-relevant, non-animal-based New Approach Methodologies (NAMs) to developmental neurotoxicity testing, demonstrating the positive attitudes of the relevant agencies toward the future implementation of NAMs in regulatory testing of DNT.

Original language	English (US)
Title of host publication	Comprehensive Toxicology
Publisher	Elsevier
Pages	Vol3:287-Vol3:312
ISBN (Electronic)	9780323954884
ISBN (Print)	9780323954891
DOIs	https://doi.org/10.1016/B978-0-323-95488-4.00187-X
State	Published - Jan 1 2025

Keywords

3D brain modal
Brain organoid
Developmental neurotoxicity
Neurotoxicity
New Approach Methodology
Regulatory testing

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-323-95488-4.00187-X

Cite this

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M3 - Chapter

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ER -

Developmental Neurotoxicology From Regulatory Testing Perspective: History, Achievements and Challenges

Abstract

Keywords

ASJC Scopus subject areas

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