Developmental influences on carotid body responses to hypoxia

Estelle B. Gauda, Edward E. Lawson

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Progress on our understanding of the mechanisms by which ventilatory responses to hypoxia and hypercapnia mature following birth will be reviewed. New reports have broadened the current understanding of these mechanisms, especially those relating to maturation of the arterial chemoreceptors in the carotid body. However, a clear understanding of the physiologic, morphologic, neurochemical and molecular developmental events remains elusive. Of particular interest is the change in carotid body sensitivity to oxygen in the first days following birth. Further, perinatal hypoxia or hyperoxia results in blunted hypoxic chemosensitivity in premature infants with chronic lung disease and in various animal models. Hence, cellular and molecular mechanisms altering the normal maturational progression will also be discussed. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)199-208
Number of pages10
JournalRespiration Physiology
Volume121
Issue number2-3
DOIs
StatePublished - Jul 2000

Keywords

  • Carotid body, development
  • Chemosensitivity, hypoxic, plasticity
  • Control of breathing, hypoxia, hypercapnia, maturation
  • Development, ventilatory response to hypoxia, hypercapnia
  • Mediators, adenosine, dopamine

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

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