TY - JOUR
T1 - Developmental influences on carotid body responses to hypoxia
AU - Gauda, Estelle B.
AU - Lawson, Edward E.
N1 - Funding Information:
We thank Drs Owen S. Bamford and Douglas C. Watson for critical review of the manuscript. Writing of this manuscript was supported partially by NIH-NHLBI grants HL03365 (EB Gauda) and HL34919 (EE Lawson).
PY - 2000/7
Y1 - 2000/7
N2 - Progress on our understanding of the mechanisms by which ventilatory responses to hypoxia and hypercapnia mature following birth will be reviewed. New reports have broadened the current understanding of these mechanisms, especially those relating to maturation of the arterial chemoreceptors in the carotid body. However, a clear understanding of the physiologic, morphologic, neurochemical and molecular developmental events remains elusive. Of particular interest is the change in carotid body sensitivity to oxygen in the first days following birth. Further, perinatal hypoxia or hyperoxia results in blunted hypoxic chemosensitivity in premature infants with chronic lung disease and in various animal models. Hence, cellular and molecular mechanisms altering the normal maturational progression will also be discussed. (C) 2000 Elsevier Science B.V.
AB - Progress on our understanding of the mechanisms by which ventilatory responses to hypoxia and hypercapnia mature following birth will be reviewed. New reports have broadened the current understanding of these mechanisms, especially those relating to maturation of the arterial chemoreceptors in the carotid body. However, a clear understanding of the physiologic, morphologic, neurochemical and molecular developmental events remains elusive. Of particular interest is the change in carotid body sensitivity to oxygen in the first days following birth. Further, perinatal hypoxia or hyperoxia results in blunted hypoxic chemosensitivity in premature infants with chronic lung disease and in various animal models. Hence, cellular and molecular mechanisms altering the normal maturational progression will also be discussed. (C) 2000 Elsevier Science B.V.
KW - Carotid body, development
KW - Chemosensitivity, hypoxic, plasticity
KW - Control of breathing, hypoxia, hypercapnia, maturation
KW - Development, ventilatory response to hypoxia, hypercapnia
KW - Mediators, adenosine, dopamine
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U2 - 10.1016/S0034-5687(00)00128-6
DO - 10.1016/S0034-5687(00)00128-6
M3 - Article
C2 - 10963775
AN - SCOPUS:0033837435
SN - 0034-5687
VL - 121
SP - 199
EP - 208
JO - Respiration Physiology
JF - Respiration Physiology
IS - 2-3
ER -