Developmental effects of vitamin B-6 restriction on the locomotor behavior of rats

Tomas R. Guilarte, Renée C. Miceli, Timothy H. Moran

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The nocturnal spontaneous locomotor behavior of vitamin B-6 restricted and control rats was measured using activity chambers. The results show a generalized hypoactivity in indices of horizontal and vertical activity in neonatal rats fed vitamin B-6 restricted diets during gestation and lactation. This pattern of locomotor behavior changed in the postweaning period to a gradual increase in indices of locomotor activity to a pronounced hyperkinesis in vitamin B-6 restricted young adult rats. This study suggests that long-term vitamin B-6 restriction results in damage and/or abnormal development of neuronal system(s) associated with locomotor behavior.

Original languageEnglish (US)
Pages (from-to)857-861
Number of pages5
JournalBrain Research Bulletin
Issue number6
StatePublished - Jun 1991


  • Deficiency
  • Development
  • Hyperactivity
  • Locomotor behavior
  • Rats
  • Vitamin B-6

ASJC Scopus subject areas

  • General Neuroscience


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