Developmental and hormonal factors in the sexually dimorphic, asymmetrical response to focal cortical lesions

Sergio E. Starkstein, Susan Ginsberg, Lena Shnayder, John Bowersox, James H. Mersey, Robert G. Robinson, Timothy H. Moran

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The developmental and hormonal determinants of the lateralized response to focal cortical suction lesions were examined in a series of experiments. In an initial study, Sprague-Dawley male rats 25, 30, 55 or 90 days of age, received right unilateral focal frontocortical suction lesions. Only 90-day-old rats developed hyperactivity, suggesting a specific role for maturational factors in the production of this response. Prepubertally castrated adult male rats receiving right frontocortical suction lesion at 90 days also failed to develop hyperactivity suggesting that sexual maturational factors and/or the presence of testosterone are necessary for the expression of this respone to adult cortical lesions in prepuberally castrated male rats. Similar lesions in the left hemisphere, however, did not produce hyperactivity in castrated male rats with testosterone replacement. Finally, in ovariectomized adult female rats, testosterone did not alow the expression of a hyperactivity response to right froncortical suction lesions. Together, these results demonstrate both an organizational and permissive role for sex steroids in the sexually dimorphic asymmetrical response to cortical injury.

Original languageEnglish (US)
Pages (from-to)16-23
Number of pages8
JournalBrain research
Issue number1
StatePublished - Jan 23 1989


  • Behavior
  • Frontal cortex
  • Lateralization
  • Locomotion
  • Testosterone

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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