Development of therapeutic HPV vaccines

Cornelia L. Trimble, Ian H. Frazer

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations


At least 15% of human malignant diseases are attributable to the consequences of persistent viral or bacterial infection. Chronic infection with oncogenic human papillomavirus (HPV) types is a necessary, but insufficient, cause in the development of more cancers than any other virus. Currently available prophylactic vaccines have no therapeutic effect for established infection or for disease. Early disease is characterised by tissue sequestration. However, because a proportion of intraepithelial HPV-associated disease undergoes immune-mediated regression, the development of immunotherapeutic strategies is an opportunity to determine proof-of-principle for therapeutic vaccines. In this Review, we discuss recent progress in this field and priorities for future clinical investigations.

Original languageEnglish (US)
Pages (from-to)975-980
Number of pages6
JournalThe Lancet Oncology
Issue number10
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Oncology


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