Development of matrix metalloproteinase inhibitors in cancer therapy

W. Thomas Purcell, Michelle A. Rudek, Manuel Hidalgo

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


The matrix metalloproteinases represent an attractive target for cancer treatment, and a number of matrix metalloproteinase inhibitors are undergoing clinical trials. The results of these studies will establish whether any of these compounds are therapeutically useful. Independent of the conclusions from the first generation of studies, the field of matrix metalloproteinase inhibitors remains attractive for creative and innovative research. In the future, the development of novel, less toxic, and more effective matrix metalloproteinase inhibitors, and the combination of conventional agents with these novel anticancer agents will constitute the main focus of research efforts.

Original languageEnglish (US)
Pages (from-to)1189-1227
Number of pages39
JournalHematology/Oncology Clinics of North America
Issue number5
StatePublished - Oct 2002

ASJC Scopus subject areas

  • Hematology
  • Oncology


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