Development of human mast cells from their progenitors

Teruko Ishizaka; Hideki Mitsui; Makoto Yanagida; Toru Miura; A. M. Dvorak

doi:10.1016/0952-7915(93)90109-6

Development of human mast cells from their progenitors

Teruko Ishizaka
, Hideki Mitsui
, Makoto Yanagida
, Toru Miura
, A. M. Dvorak

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Two types of human mast cells, which are morphologically similar to skin mast cells and lung mast cells, repectively, can be developed from pluripotent stem cells under different culture conditions. The major growth factor for mast-cell development is c-kit ligand, which induces mastocytosis in vivo. However, this cytokine is not sufficient for full maturation of the cells.

Original language	English (US)
Pages (from-to)	937-943
Number of pages	7
Journal	Current Opinion in Immunology
Volume	5
Issue number	6
DOIs	https://doi.org/10.1016/0952-7915(93)90109-6
State	Published - Dec 1993
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0952-7915(93)90109-6

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title = "Development of human mast cells from their progenitors",

abstract = "Two types of human mast cells, which are morphologically similar to skin mast cells and lung mast cells, repectively, can be developed from pluripotent stem cells under different culture conditions. The major growth factor for mast-cell development is c-kit ligand, which induces mastocytosis in vivo. However, this cytokine is not sufficient for full maturation of the cells.",

author = "Teruko Ishizaka and Hideki Mitsui and Makoto Yanagida and Toru Miura and Dvorak, \{A. M.\}",

note = "Funding Information: The authors express their special gratitude to Drs Anne-Marie A Irdni and Lawrence 1) Schwartz, Medical College of Virginia, Virginia Commonwealth University, Richmond, ViiInia for their collaboration and contribution. This is publication number 85 from La Jolla Institute for Allergy and Immunology, supported by Health and Human Service grants AI-loo60 and AI-33372, and a research contract with Gemini Science, Inc. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1993",

month = dec,

doi = "10.1016/0952-7915(93)90109-6",

language = "English (US)",

volume = "5",

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journal = "Current Opinion in Immunology",

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AU - Ishizaka, Teruko

AU - Mitsui, Hideki

AU - Yanagida, Makoto

AU - Miura, Toru

AU - Dvorak, A. M.

N1 - Funding Information: The authors express their special gratitude to Drs Anne-Marie A Irdni and Lawrence 1) Schwartz, Medical College of Virginia, Virginia Commonwealth University, Richmond, ViiInia for their collaboration and contribution. This is publication number 85 from La Jolla Institute for Allergy and Immunology, supported by Health and Human Service grants AI-loo60 and AI-33372, and a research contract with Gemini Science, Inc. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1993/12

Y1 - 1993/12

N2 - Two types of human mast cells, which are morphologically similar to skin mast cells and lung mast cells, repectively, can be developed from pluripotent stem cells under different culture conditions. The major growth factor for mast-cell development is c-kit ligand, which induces mastocytosis in vivo. However, this cytokine is not sufficient for full maturation of the cells.

AB - Two types of human mast cells, which are morphologically similar to skin mast cells and lung mast cells, repectively, can be developed from pluripotent stem cells under different culture conditions. The major growth factor for mast-cell development is c-kit ligand, which induces mastocytosis in vivo. However, this cytokine is not sufficient for full maturation of the cells.

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AN - SCOPUS:0027425322

SN - 0952-7915

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JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

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ER -

Development of human mast cells from their progenitors

Abstract

ASJC Scopus subject areas

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