Development of human mast cells from their progenitors

Teruko Ishizaka, Hideki Mitsui, Makoto Yanagida, Toru Miura, A. M. Dvorak

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Two types of human mast cells, which are morphologically similar to skin mast cells and lung mast cells, repectively, can be developed from pluripotent stem cells under different culture conditions. The major growth factor for mast-cell development is c-kit ligand, which induces mastocytosis in vivo. However, this cytokine is not sufficient for full maturation of the cells.

Original languageEnglish (US)
Pages (from-to)937-943
Number of pages7
JournalCurrent Opinion in Immunology
Issue number6
StatePublished - Dec 1993
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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