Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9

Larry H. Yamaoka; Carol A. Westbrook; Marcy C. Speer; James M. Gilchrist; Ethylin W. Jabs; Elizabeth G. Schweins; Jeffrey M. Stajich; Perry C. Gaskell; Allen D. Roses; Margaret A. Pericak-Vance

doi:10.1016/0960-8966(94)90086-8

Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9

Larry H. Yamaoka
, Carol A. Westbrook
, Marcy C. Speer
, James M. Gilchrist
, Ethylin W. Jabs
, Elizabeth G. Schweins
, Jeffrey M. Stajich
, Perry C. Gaskell
, Allen D. Roses
, Margaret A. Pericak-Vance

School of Medicine

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.

Original language	English (US)
Pages (from-to)	471-475
Number of pages	5
Journal	Neuromuscular Disorders
Volume	4
Issue number	5-6
DOIs	https://doi.org/10.1016/0960-8966(94)90086-8
State	Published - 1994

ASJC Scopus subject areas

Clinical Neurology
Pediatrics, Perinatology, and Child Health
Developmental Neuroscience
Neurology

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Yamaoka, L. H., Westbrook, C. A., Speer, M. C., Gilchrist, J. M., Jabs, E. W., Schweins, E. G., Stajich, J. M., Gaskell, P. C., Roses, A. D., & Pericak-Vance, M. A. (1994). Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. Neuromuscular Disorders, 4(5-6), 471-475. https://doi.org/10.1016/0960-8966(94)90086-8

Yamaoka, LH, Westbrook, CA, Speer, MC, Gilchrist, JM, Jabs, EW, Schweins, EG, Stajich, JM, Gaskell, PC, Roses, AD & Pericak-Vance, MA 1994, 'Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9', Neuromuscular Disorders, vol. 4, no. 5-6, pp. 471-475. https://doi.org/10.1016/0960-8966(94)90086-8

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title = "Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9",

abstract = "Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.",

author = "Yamaoka, \{Larry H.\} and Westbrook, \{Carol A.\} and Speer, \{Marcy C.\} and Gilchrist, \{James M.\} and Jabs, \{Ethylin W.\} and Schweins, \{Elizabeth G.\} and Stajich, \{Jeffrey M.\} and Gaskell, \{Perry C.\} and Roses, \{Allen D.\} and Pericak-Vance, \{Margaret A.\}",

year = "1994",

doi = "10.1016/0960-8966(94)90086-8",

language = "English (US)",

volume = "4",

pages = "471--475",

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AU - Yamaoka, Larry H.

AU - Westbrook, Carol A.

AU - Speer, Marcy C.

AU - Gilchrist, James M.

AU - Jabs, Ethylin W.

AU - Schweins, Elizabeth G.

AU - Stajich, Jeffrey M.

AU - Gaskell, Perry C.

AU - Roses, Allen D.

AU - Pericak-Vance, Margaret A.

PY - 1994

Y1 - 1994

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AB - Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.

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SN - 0960-8966

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Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9

Abstract

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