Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9

Larry H. Yamaoka; Carol A. Westbrook; Marcy C. Speer; James M. Gilchrist; Ethylin W. Jabs; Elizabeth G. Schweins; Jeffrey M. Stajich; Perry C. Gaskell; Allen D. Roses; Margaret A. Pericak-Vance

doi:10.1016/0960-8966(94)90086-8

Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9

Larry H. Yamaoka, Carol A. Westbrook, Marcy C. Speer, James M. Gilchrist, Ethylin W. Jabs, Elizabeth G. Schweins, Jeffrey M. Stajich, Perry C. Gaskell, Allen D. Roses, Margaret A. Pericak-Vance

School of Medicine

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.

Original language	English (US)
Pages (from-to)	471-475
Number of pages	5
Journal	Neuromuscular Disorders
Volume	4
Issue number	5-6
DOIs	https://doi.org/10.1016/0960-8966(94)90086-8
State	Published - 1994

ASJC Scopus subject areas

Clinical Neurology
Pediatrics, Perinatology, and Child Health
Developmental Neuroscience
Neurology

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Yamaoka, L. H., Westbrook, C. A., Speer, M. C., Gilchrist, J. M., Jabs, E. W., Schweins, E. G., Stajich, J. M., Gaskell, P. C., Roses, A. D., & Pericak-Vance, M. A. (1994). Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. Neuromuscular Disorders, 4(5-6), 471-475. https://doi.org/10.1016/0960-8966(94)90086-8

Yamaoka, LH, Westbrook, CA, Speer, MC, Gilchrist, JM, Jabs, EW, Schweins, EG, Stajich, JM, Gaskell, PC, Roses, AD & Pericak-Vance, MA 1994, 'Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9', Neuromuscular Disorders, vol. 4, no. 5-6, pp. 471-475. https://doi.org/10.1016/0960-8966(94)90086-8

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title = "Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9",

abstract = "Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.",

author = "Yamaoka, {Larry H.} and Westbrook, {Carol A.} and Speer, {Marcy C.} and Gilchrist, {James M.} and Jabs, {Ethylin W.} and Schweins, {Elizabeth G.} and Stajich, {Jeffrey M.} and Gaskell, {Perry C.} and Roses, {Allen D.} and Pericak-Vance, {Margaret A.}",

year = "1994",

doi = "10.1016/0960-8966(94)90086-8",

language = "English (US)",

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AU - Yamaoka, Larry H.

AU - Westbrook, Carol A.

AU - Speer, Marcy C.

AU - Gilchrist, James M.

AU - Jabs, Ethylin W.

AU - Schweins, Elizabeth G.

AU - Stajich, Jeffrey M.

AU - Gaskell, Perry C.

AU - Roses, Allen D.

AU - Pericak-Vance, Margaret A.

PY - 1994

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N2 - Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.

AB - Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.

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Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9

Abstract

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