Development and implementation of a high-performance, cardiac-gated dual-energy imaging system

N. A. Shkuma, J. H. Siewerdsen, A. C. Dhanantwari, D. B. Williams, S. Richard, D. J. Tward, N. S. Paul, J. Yorkston, R. Van Metter

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


Mounting evidence suggests that the superposition of anatomical clutter in a projection radiograph poses a major impediment to the detectability of subtle lung nodules. Through decomposition of projections acquired at multiple kVp, dual-energy (DE) imaging offers to dramatically improve lung nodule detectability and, in part through quantitation of nodule calcification, increase specificity in nodule characterization. The development of a high-performance DE chest imaging system is reported, with design and implementation guided by fundamental imaging performance metrics. A diagnostic chest stand (Kodak RVG 5100 digital radiography system) provided the basic platform, modified to include: (i) a filter wheel, (ii) a flat-panel detector (Trixell Pixium 4600), (iii) a computer control and monitoring system for cardiac-gated acquisition, and (iv) DE image decomposition and display. Computational and experimental studies of imaging performance guided optimization of key acquisition technique parameters, including: x-ray filtration, allocation of dose between low- and high-energy projections, and kVp selection. A system for cardiac-gated acquisition was developed, directing x-ray exposures to within the quiescent period of the heart cycle, thereby minimizing anatomical misregistration. A research protocol including 200 patients imaged following lung nodule biopsy is underway, allowing preclinical evaluation of DE imaging performance relative to conventional radiography and low-dose CT.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2007
Subtitle of host publicationPhysics of Medical Imaging
EditionPART 1
ISBN (Print)081946628X, 9780819466280
StatePublished - 2007
Externally publishedYes
EventMedical Imaging 2007: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 18 2007Feb 22 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
NumberPART 1
ISSN (Print)1605-7422


OtherMedical Imaging 2007: Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego, CA


  • Cardiac gating
  • Dual-energy imaging
  • Flat-panel detector
  • Image acquisition technique
  • Image quality
  • Imaging dose
  • Imaging performance
  • Lung cancer
  • Optimization
  • Thoracic imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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