@inproceedings{c0ddae64f1d048aeb43e83125e46b8ba,
title = "Development and implementation of a high-performance, cardiac-gated dual-energy imaging system",
abstract = "Mounting evidence suggests that the superposition of anatomical clutter in a projection radiograph poses a major impediment to the detectability of subtle lung nodules. Through decomposition of projections acquired at multiple kVp, dual-energy (DE) imaging offers to dramatically improve lung nodule detectability and, in part through quantitation of nodule calcification, increase specificity in nodule characterization. The development of a high-performance DE chest imaging system is reported, with design and implementation guided by fundamental imaging performance metrics. A diagnostic chest stand (Kodak RVG 5100 digital radiography system) provided the basic platform, modified to include: (i) a filter wheel, (ii) a flat-panel detector (Trixell Pixium 4600), (iii) a computer control and monitoring system for cardiac-gated acquisition, and (iv) DE image decomposition and display. Computational and experimental studies of imaging performance guided optimization of key acquisition technique parameters, including: x-ray filtration, allocation of dose between low- and high-energy projections, and kVp selection. A system for cardiac-gated acquisition was developed, directing x-ray exposures to within the quiescent period of the heart cycle, thereby minimizing anatomical misregistration. A research protocol including 200 patients imaged following lung nodule biopsy is underway, allowing preclinical evaluation of DE imaging performance relative to conventional radiography and low-dose CT.",
keywords = "Cardiac gating, Dual-energy imaging, Flat-panel detector, Image acquisition technique, Image quality, Imaging dose, Imaging performance, Lung cancer, Optimization, Thoracic imaging",
author = "Shkuma, {N. A.} and Siewerdsen, {J. H.} and Dhanantwari, {A. C.} and Williams, {D. B.} and S. Richard and Tward, {D. J.} and Paul, {N. S.} and J. Yorkston and {Van Metter}, R.",
note = "Funding Information: The authors are grateful to Saifeng Zhang, Yafeng Xie, and Ranru Tang from Shanghai Institute of Optics and Fine Mechanics for his support in the experiments. This work was financially supported by the National Natural Science Foundation of China (Grant Nos. 61178024 and 11374316).; Medical Imaging 2007: Physics of Medical Imaging ; Conference date: 18-02-2007 Through 22-02-2007",
year = "2007",
doi = "10.1117/12.713680",
language = "English (US)",
isbn = "081946628X",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
number = "PART 1",
booktitle = "Medical Imaging 2007",
edition = "PART 1",
}