Developing strategies for HIV-1 eradication

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72 Scopus citations


Highly active antiretroviral therapy (HAART) suppresses HIV-1 replication, transforming the outlook for infected patients. However, reservoirs of replication-competent forms of the virus persist during HAART, and when treatment is stopped, high rates of HIV-1 replication return. Recent insights into HIV-1 latency, as well as a report that HIV-1 infection was eradicated in one individual, have renewed interest in finding a cure for HIV-1 infection. Strategies for HIV-1 eradication include gene therapy and hematopoietic stem cell transplantation, stimulating host immunity to control HIV-1 replication, and targeting latent HIV-1 in resting memory CD4+ T cells. Future efforts should aim to provide better understanding of how to reconstitute the CD4+ T cell compartment with genetically engineered cells, exert immune control over HIV-1 replication, and identify and eliminate all viral reservoirs.

Original languageEnglish (US)
Pages (from-to)554-562
Number of pages9
JournalTrends in Immunology
Issue number11
StatePublished - Nov 2012


  • Cure
  • Eradication
  • HIV-1
  • Latency
  • Reservoir

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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