Developing neuroprotective strategies for treatment of HIV-associated neurocognitive dysfunction

Jeffrey A. Rumbaugh, Joseph P. Steiner, Ned Sacktor, Avindra Nath

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Important advances have been made in recent years in identifying the molecular mechanisms of HIV neuropathogenesis. Defining the pathways leading to HIV dementia has created an opportunity to therapeutically target many steps in the pathogenic process. HIV itself rarely infects neurons, but significant neuronal damage is caused both by viral proteins and by inflammatory mediators produced by the host in response to infection. Highly active antiretroviral therapy (HAART) does not target these mediators of neuronal damage, and the prevalence of HIV-associated neurocognitive dysfunction has actually been rising in the post-HAART era. This review will briefly summarize our current understanding of the mechanisms of HIV-induced neurological disease, and emphasize translation of this basic research into potential clinical applications.

Original languageEnglish (US)
Pages (from-to)271-280
Number of pages10
JournalFuture HIV Therapy
Issue number3
StatePublished - 2008


  • Cytokines
  • Excitotoxicity
  • Gp 120
  • HIV demenia
  • MMP
  • Nitrosative stress
  • Oxidative stress
  • Tat

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Virology
  • Infectious Diseases
  • Pharmacology (medical)


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